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Example sentences for: erks

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In one study, the β 2 -AR activates ERK through it's coupling to a PTX-sensitive G i protein and subsequent Ras activation [ 24 ] , while, in another, ERK phosphorylation occurred in a PTX-independent and a G s - and cAMP-dependent fashion [ 25 ] . Furthermore, these studies indicate that the same receptor may activate ERKs via one mechanism when it is endogenously expressed and via another when it is transfected into a cell line [ 25 ] .
The levels of phospho-ERKs increased within 5 min of TNFα treatment, peaked by 10 min and decreased by 30 min (Fig.
1C), which is consistent with the observation that ERKs are constitutively activated.
In EGF pre-treated cultures, acute EGF (10 ng/ml) was unable to increase the expression of phospho-ERKs compared to media-exposed controls (Figure 6).
However, at high density ERKs are less active and can be further activated by phorbol ester (not shown).