Words similar to er-
Example sentences for: er-
How can you use “er-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Roughly 40% (14/36) of the top characterized genes associated with this group encode protein-folding chaperones localized to different subcellular regions (including those that encode the cytosolic Hsp90 and Hsp70 factors, the mitochondrial Hsp10/Hsp60p and Ssc1p, and the ER- and mitochondrial-associated Ssa1p), and their induction following heat shock and diamide treatment is likely to be in response to widespread protein unfolding inflicted by these conditions.
The βRARE-TK-Luc reporter plasmid with three copies of the DR-5 motif from the promoter of the mouse RARβ2 gene has been described previously, as has the CYP2B10-TK-Luc reporter with two copies of the DR-4 type elements from the promoter of the mouse CYP2B10 gene and the CYP3A4-TK-luc reporter with three copies of the ER-6 element from the human CYP3A4 promoter [ 16 ] . Expression vectors for full length mCAR and RXR proteins were as described [ 9 ] . The cdm8-mCARΔ8 deletion construct containing a deletion of the last 8 amino acids and the mutant with 2 helix 3 mutations (F171L, I174A) that block ligand binding and response have been described previously [ 16 ] , as has the cdm8-RXRΔ19 construct with a deletion of the last 19 amino acids [ 3 ] .
No antibodies detected nmt55/p54 nrbprotein in ER- human breast tumors (lanes 1-5) confirming previous observations [ 13 ] . Monoclonal antibody NMT-1 and polyclonal antibody NMT-5 detect nmt55/p54 nrbprotein in all ER+ tumor samples (lanes 5-10), albeit at varying levels.
Since there was no apparent nmt55/p54 nrbmRNA regulation in ER+ or ER- human breast tumors, it was possible that monoclonal antibody NMT-1 may not detect the presence of potential multiple isoforms of nmt55/p54 nrbprotein especially in ER- tumors.
We have previously shown that nmt55/p54 nrbprotein was expressed in most ER+/PR+ human breast tumors but was undetectable in ER-/PR- human breast tumors [ 13 ] . Since loss of hERα expression is associated with poor prognosis and continued expression of hERα is associated with disease-free survival and correlates well with tumor differentiation state, we wanted to investigate the regulation of nmt55/p54 nrbexpression.
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