Words similar to er-
Example sentences for: er-
How can you use “er-” in a sentence? Here are some example sentences to help you improve your vocabulary:
nmt55/p54 nrbtranscripts were detected at varying levels in both ER+ and ER- tumors.
These studies demonstrated a statistically significant association between nmt55/p54 nrbprotein expression, tumor hormonal phenotype and mean tumor size [ 13 ] . Specifically, in tumors large in size or those tumors which were determined to be ER-, the expression of nmt55/p54 nrbprotein was absent, or greatly reduced [ 13 ] . These results suggested that loss of nmt55/p54 nrbprotein expression may be related to hormone insensitivity, tumor differentiation state, unregulated tumor growth and metastases.
These results, together with those reported previously [ 13 ] , further suggest that decreased expression of nmt55/p54 nrbprotein in ER- human breast tumors is likely a post-transcriptional event.
Our data suggests that nmt55/p54 nrbmay be critical to cell growth and function, such that, decreased nmt55/p54 nrbexpression in ER- human breast tumors or the expression of nmt55/p54 nrbvariants in ER+ tumors may indicate loss of normal growth, nmt55/p54 nrbhas been shown in several studies to bind RNA and interact with PSF and Topoisomerase I [ 14 16 17 18 19 20 39 ] . Those results along with our observations that nmt55/p54 nrbassociates with several splicing factors essential for spliceosome formation (unpublished) and relates to tumor hormonal status [ 13 ] suggest that nmt55/p54 nrbmay be involved in pre-mRNA processing.
Specifically, the decreased nmt55/p54 nrbprotein expression observed in ER- human breast tumors may not be attributed to transcriptional regulation of nmt55/p54 nrbmRNA since mRNA expression in ER- tumors is not universally decreased.
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