Words similar to enterocyte
Example sentences for: enterocyte
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Additionally, while screening an enterocyte cDNA library for full length cDNAs using PCR, we consistently amplified two DNA products when using Abcg8 primers flanking exon 2; one of the expected size, and another very low copy product ~60 bases larger.
The coordinated vitamin D-dependent induction of the cytosolic calcium-binding protein calbindin D could serve this function when the need for transcellular calcium flux is high by acting directly or indirectly as a molecular sponge and selectively removing calcium ions from the CaT1 channel and/or to buffer increases in intracellular calcium, thereby preventing premature inactivation of this I CRAC channel [ 15 ] . Calbindin D could also play its traditionally conceived role as a calcium chaperone protein to facilitate the transfer of calcium through the cytosol [ 32 ] and perhaps delivery of Ca ++to the basolateral ATP-dependent calcium pump for extrusion out of the enterocyte [ 33 ] .
5 kb for Abcg8 . However, the poly A +RNA loaded onto this Northern blot has been adjusted to obtain an identical β-actin signal, and the intestinal RNA loaded may thus have less enterocyte RNA.
Studies in human duodenal biopsy specimens have found a significant correlation between CaT1 mRNA and calbindin D mRNA expression [ 16 ] . Thus, as a working hypothesis, we propose that during times of dietary calcium stress, or during periods of high calcium demand, CaT1 expression in the enterocyte is increased by a vitamin D-dependent mechanism.
This regulatory genomic response of the enterocyte would result in an increase in the brush border membrane content of CaT1 calcium influx channels that could function as a gatekeeper mechanism to augment the rate of calcium entry across the apical membrane [ 9 ] . However, given that there is a Ca-dependent negative feedback mechanism to limit calcium entry through the channel by maintaining the channel in the closed position [ 14 15 ] there must be a way to remove calcium from the vicinity of the cytosolic face of the channel to optimize and sustain calcium influx rates.
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