Words similar to entail
Example sentences for: entail
How can you use “entail” in a sentence? Here are some example sentences to help you improve your vocabulary:
It can entail prospective and retrospective designs and it permits synthesis of many individual case studies undertaken at different times and in different sites.
Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.
Detail study of these candidate genes will entail generation of recombinant cDNA constructs, generation of cell lines, antibodies, fusion proteins, and perform in-situ hybridization among others.
Nevertheless, pharmacological antagonism of glucocorticoid (type II) receptor by mifepristone (RU486) was reported to reverse high fat diet-induced obesity [ 14 ] . Since diet-induced obesity does not entail elevated glucocorticoid levels [ 15 16 17 ] , this result suggests that reduction of glucocorticoid levels would reverse obesity even when glucocorticoid levels are not elevated.
The adversarial system permitted such questions to be asked and answered--admittedly a vexatious experience for the survivors but one that does entail an airing of the facts of the Holocaust.
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