Example sentences for: endoplasmic

How can you use “endoplasmic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A recent study of the effect of BDM on the distribution of myosins, F-actin, microtubules and cortical endoplasmic reticulum (ER) suggests that myosins may link together microtubules and actin filaments involved in structural interactions [ 75].

  • For direct testing, temperature sensitive mutants in genes involved in vesicular budding from the endoplasmic reticulum were obtained from others and crossed to all mutants isolated in the screen.

  • However, two lines of evidence suggest that the endoplasmic reticulum might be a neuronal target of mefloquine.

  • The resulting enzyme is both mislocalized and unstable [ 27 ] . Another mutation, Q1098P, was found to cause retention of SI in the transport pathway between the endoplasmic reticulum and Golgi apparatus [ 28 ] . An unusual mutation, Q117R, that alters the structure close to the O-glycosylated stalk domain, leads to random distribution of the enzyme to both the apical and basolateral cell membranes [ 29 ] . An unusual human mutation that causes SI to be secreted rather than retained in the plasma membrane demonstrates that the enzyme is required to be at the enterocyte cell surface [ 30 ] .

  • Mancini et al . reported that caspase-2 was localized at the Golgi complex and generated a unique cleavage product of golgin-160 [ 29 ] . Furthermore, these investigators proposed that the Golgi complex transduces proapoptotic signals [ 29 ] . A precedent for this hypothesis was provided by Nakagawa et al ., who reported that caspase-12 is localized to the endoplasmic reticulum and mediates an endoplasmic reticulum-specific apoptosis pathway [ 33 ] . In the present study, we have found that all Golgi autoantigens examined were cleaved in apoptosis in a caspase-dependent manner, as evidenced by studies showing that the pan-caspase inhibitor zVAD-fmk completely blocked the apoptotic fragmentation of these antigens.


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