Words similar to encephalomyelitis
Example sentences for: encephalomyelitis
How can you use “encephalomyelitis” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, experimental autoimmune encephalomyelitis has been widely used as a model of multiple sclerosis.
have shown that orchidectomy in mice can diminish the flow of CD4 +activated in experimental autoimmune encephalomyelitis [ 39].
Treatment with recombinant IL-10 in CIA, in proteoglycan-induced arthritis, and in experimental autoimmune encephalomyelitis reduced disease severity, and neutralizing IL-10 with antibodies exacerbated disease [ 19 20 22 23 ] . The present data are consistent with previous results and show that a complete absence of IL-10 exacerbates inflammation in CIA [ 37 38 39 ] . The anti-inflammatory properties of IL-10 suggest that endogenous IL-10 may function as a regulator of proinflammatory mediators in vivo [ 39 ] . It is interesting, however, that disease severity inversely correlates with the levels of IFN-γ in IL-10 -/-mice, suggesting that IL-10 may control disease activity via regulating IFN-γ responses.
For example, administration of GAD65 to young NOD mice has been shown to prevent insulitis and diabetes [ 8 9 ] , apparently via induction of CD4+ regulatory T cells with a T H 2 phenotype [ 10 ] . Similarly, treatment with immunodominant peptides of myelin can prevent or reverse experimental autoimmune encephalomyelitis (EAE), a T H 1-associated inducible "autoimmune" disorder that is widely used as a model for human multiple sclerosis [ 11 12 13 ] .
In support of this notion, immunization of CD28-deficient mice with high concentrations of myelin basic protein induces experimental autoimmune encephalomyelitis at similar prevalence and severity as in wild-type mice [ 30 ] . Our data suggest that the CD4 +CD25 +regulatory T cells might be important for controlling spontaneous models of autoimmunity but not for induced models of autoimmunity.
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