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Example sentences for: ena-

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Several observations support the assertion that a complex interaction between IL-8 and several other growth factors, cytokines, or other proteins is responsible for these tumor-related events [ 5 9 10 11 12 13 ] . Growth regulated protein alpha (GRO-α), beta (GRO-β), and ENA-78 have been reported to be co-induced with IL-8 in A549 cells stimulated with two proinflammatory cytokines, IL-1β and TNF-α [ 14 ] . This result is consistent with the presence of nuclear factor kappa B (NF-κB) consensus binding sites in the promoter regions of all three genes [ 4 15 ] . In addition, GRO-α and -β are also members of the ELR +CXC cytokine family that are reported to be important mediators of tumorigenesis through their angiogenic properties [ 2 16 ] . They both share one of the IL-8 receptors, CXCR2, which has been postulated to regulate the ELR +CXC chemokine-mediated angiogenesis and resulting-tumorigenesis [ 1 ] . These observations suggest that GRO-α and -β may exhibit expression profiles similar to IL-8.
The co-expression of IL-8 with IL-6, GRO-α, and GRO-β in many tissues has been well documented [ 5 14 19 ] , and those genes are identified here as IL-8 related genes with an IL-8 Z-score >= 3. The GRO-γ and ENA-78 [ 14 ] also show a high IL-8 Z-score, although the available EST clone number for these two genes is much smaller.