Words similar to emphysematous
Example sentences for: emphysematous
How can you use “emphysematous” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although increased activities of citrate synthase [ 7 ] and SDH [ 2 3 ] have usually been demonstrated in the diaphragm in animal models of emphysema, fiber type has generally not been found to be significantly altered [ 1 2 3 7 ] . Only in one recent paper was a shift in MHC in emphysematous diaphragm demonstrated, but the histochemical technique used precluded the separation of IIb and IIx fibers [ 10 ] . Another study has shown increased expression of IIa at the expense of IIx MHC in emphysematous hamster scalene muscle with the use of MHC monoclonal antibodies, but there were none of the expected physiologic changes accompanying the shift [ 11 ] .
Our results for MHC expression in rat diaphragm from normal and emphysematous rats must be viewed first in the light of previous quantitative studies of MHC expression in normal rat diaphragm that used techniques able to separate out all known isoforms.
We demonstrate here a shift from IIb toward IIx in emphysematous rat diaphragm at both the protein and mRNA levels.
Previous work has suggested that although SERCA expression in limb muscles seems to respond to increases in functional load by upregulating SERCA 2 (the slow SERCA isoform) and downregulating SERCA 1 (the fast isoform) [ 50 ] , similar responses might not occur in diaphragm [ 51 ] . Our data showing no difference in the expression of SERCA 1 and SERCA 2 between emphysematous and control animals are consistent with this finding.
This trend was most marked in the IIx isoform, for which the P value for increased expression in emphysematous versus control diaphragm reached 0.06.
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