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Example sentences for: emerin

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As specialized proteins of the intermediate filament protein family, lamin A/C is found at the inner nuclear membrane where it forms a scaffold that interacts with a network of membrane bound and nucleoplasmic proteins in addition to chromatin [ 3 4 5 ] . Mutations in the gene encoding the nuclear membrane protein emerin produce autosomal recessive Emery Dreifuss Muscular Dystrophy, a disorder that phenotypically overlaps the neuromuscular and cardiovascular features seen with lamin A/C mutations [ 6 ] . Consistent with this, lamin A/C directly binds emerin [ 7 8 ] . Lamins A and C are broadly expressed in many different cell types and are primarily expressed in terminally differentiated cells.
They also do not show significant sequence similarity to other vertebrate nuclear envelope-associated proteins such as LAP1, LAP2, MAN1, and emerin (GenBank accession numbers A55649, S55255, Q9WU40, and XP_048410, respectively).
These genes include those for glucose-6-phosphate dehydrogenase, XAP-5, renin-binding protein, N -acetyltransferase (homolog of Saccharomyces cerevisiae ARD1 ), signal sequence receptor-delta, isocitrate dehydrogenase 3 (NAD +) gamma, biglycan, tafazzin, deoxyribonuclease I-like 1, and emerin [ 51].
The presence of aberrantly assembled lamin filaments may also interfere with other lamin-interacting proteins such as emerin or nesprin-1α [ 23 ] .