Words similar to embryonal
Example sentences for: embryonal
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A unique feature of GCTs is their origin from germ cells at a stage in development where they undergo epigenetic reprogramming [ 6 13 ] . The absence of this epigenetic modification in SGCTs is consistent with their GC-like nature as previously noted [ 6 14 ] . On the other hand, the extensive promoter hypermethylation seen in NSGCTs suggests a mechanistic role in their potential for embryonal and extra-embryonal lineage differentiation [ 6 14 ] . Establishment of DNA methylation in the mammalian genome is controlled by at least three DNA methyltransferases (DNMTs), DNMT1 , DNMT3a and DNMT3b [ 15 ] . The role of these DNMTs in differential de novo methylation in SGCT vs.
In mammalian cells, a TS mutation in TAF II 250 shows that one of the functions of this protein is cell cycle regulation [ [ 21 22 23 24 ] ]. Genetic experiments indicate that TAF II 30 is required for the viability of mouse F9 embryonal carcinoma cells as well as for their differentiation into parietal endoderm [ 25].
For example, mouse embryonal stem (ES) cells with homozygous deletion of the PTEN gene exhibit increased anchorage-independent growth as compared to normal ES cells [ 12 ] . Similarly, transfer of a wild type PTEN gene into anchorage-independent human glioblastoma cells (which lack functional PTEN), results in their greatly reduced ability to form colonies in soft agar [ 4 5 6 ] . The interpretation of these latter findings, however, is complicated by the strong anti-proliferative effects of PTEN even in monolayer culture, which is consistently observed when the wild type version of this gene is introduced into PTEN-negative tumor cells [ 4 6 7 8 9 10 18 33 ] . Moreover, in human glioma and breast cancer cell lines, the ectopic expression of wild type PTEN leads to anoikis, which is apoptosis initiated by the disruption of cell matrix-interactions [ 23 34 35 36 ] .
We used reverse transcription-PCR method to analyze five different rhabdomyosarcoma cell lines, RD cells (embryonal), Rh28, Rh30 (alveolar), Rh3, Rh4, and mouse normal myoblast C2C12 cells.
There is no difference in staining pattern in regard to the subtypes of the rhabdomyosarcomas, namely embryonal or alveolar subtypes.
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