Words similar to embryo-derived

Example sentences for: embryo-derived

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The mutagens permit direct selection of clones in which cellular genes have been disrupted and simplify the characterisation of genes associated with recessive mutations [ 1 ] . Mutagenesis of embryo-derived stem (ES) cells, coupled with in vitro genetic screens, has been widely used to analyse gene functions in mice [ 1 ] . These have included screens for mutations in developmentally regulated genes [ 2 3 4 5 ] , in genes regulated by extracellular agonists [ 6 7 ] , and in genes encoding secreted and transmembrane proteins [ 8 9 ] . Characterized mutations include genes involved in intracellular trafficking [ 10 ] , transcriptional regulation [ 11 12 ] , signal transduction [ 7 8 11 13 14 15 ] , neural development [ 16 ] and neural wiring [ 17 ] , and axial patterning [ 18 19 ] . The rapid expansion of the nucleic acid databases has had a tremendous impact on the identification of genes disrupted by gene entrapment.
Several large scale screens of insertion mutations in mouse embryo-derived stem (ES) cells rely on DNA sequence analysis to select mutations for germline transmission [ 21 22 23 24 ] . The process, designated "tagged sequence mutagenesis", involves sequencing short segments of DNA isolated from each mutation to identify genes disrupted by the targeting vector.