Example sentences for: elr
How can you use “elr” in a sentence? Here are some example sentences to help you improve your vocabulary:
The genes for complement C3 and IP-10 (IFN-induced protein of 10 kDa), a non-ELR CXC chemokine, were among the genes upregulated by IL-4 in the monkey lung.
MIG/CXCL 9 and IP-10/CXCL10 are glutamine-leucine-arginine (ELR)-negative CXC chemokines that are potent chemoattractants for activated T cells [ 11 12 13 ] . These chemokines also have in common the ability to signal through a G protein-coupled receptor, CXCR3, expressed on activated T lymphocytes.
Several observations support the assertion that a complex interaction between IL-8 and several other growth factors, cytokines, or other proteins is responsible for these tumor-related events [ 5 9 10 11 12 13 ] . Growth regulated protein alpha (GRO-α), beta (GRO-β), and ENA-78 have been reported to be co-induced with IL-8 in A549 cells stimulated with two proinflammatory cytokines, IL-1β and TNF-α [ 14 ] . This result is consistent with the presence of nuclear factor kappa B (NF-κB) consensus binding sites in the promoter regions of all three genes [ 4 15 ] . In addition, GRO-α and -β are also members of the ELR +CXC cytokine family that are reported to be important mediators of tumorigenesis through their angiogenic properties [ 2 16 ] . They both share one of the IL-8 receptors, CXCR2, which has been postulated to regulate the ELR +CXC chemokine-mediated angiogenesis and resulting-tumorigenesis [ 1 ] . These observations suggest that GRO-α and -β may exhibit expression profiles similar to IL-8.
Interleukin-8 (IL-8) is a potent member of the supergene family of CXC chemokines with ELR motif (ELR+).
ELR +CXC chemokines are potent angiogenic factors, whereas ELR -CXC chemokines are potent angiostatic factors.
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