Words similar to elastase
Example sentences for: elastase
How can you use “elastase” in a sentence? Here are some example sentences to help you improve your vocabulary:
Eleven 3-month-old Sprague-Dawley rats underwent emphysema induction by a single intratracheal instillation of porcine pancreatic elastase (ICN Biochemicals, Cleveland, Ohio) at 25 units per 100 g body weight, diluted in 0.60 ml of normal saline as described previously [ 4 ] . Two animals died on the night after instillation, with evidence at autopsy the following day of diffuse pulmonary hemorrhage.
Short-term co-cultures of monocytes with fibroblasts result in the inhibition of collagen gel contraction [ 3], while co-cultures of fibroblasts with neutrophils, or with neutrophil elastase (NE), augment contraction [ 4].
Destruction of lung parenchyma in emphysema is thought to occur through excessive proteolysis mediated by the elastin-degrading enzymes MMP2, MMP9, and MMP12 from the MMP family, and by neutrophil elastase from the serine proteinase family [45,46].
Second, the principal Th1 chemokines, MIG and IP-10, are linked to a pro-elastolytic lung environment because these cytokines upregulate the elastase MMP12, which is associated with emphysema.
Studies done with ARDS patients have shown that there is an increase in the number of PMNs in the lung and bronco-alveolar fluid, which cause an increase in elastase and other lysozomal enzymes [ 12 ] . Kopolovic et al.