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Example sentences for: eigen
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One potential drawback of this method is that the number of clusters, k , is limited to the number of eigen vectors (which is determined by the number of microarray experiments analyzed).
The inability of the method to find the expression patterns representing these groups seemed to be dependent on the overall properties of the dataset, rather than the absence of an appropriate eigen vector used to initiate the process, as the program was unable to identify these patterns even when the process was initiated by seeding the centroids with the unidentified patterns (data not shown).
Together, the eigen vectors describe the variation in the gene-expression dataset, and therefore seeding the centroids with these vectors provides a systematic method of sampling the data space.
We examined a number of different initialization methods (data not shown) and found that seeding prototype centroids with the eigen vectors identified by PCA performed optimally.
The first round of clustering is initialized by defining k /3 prototype centroids (where k is the total number of clusters and 3 is the number of clustering cycles) as the most informative k /3 eigen vectors identified by PCA of the input dataset (see Materials and methods).