Words similar to eigen
Example sentences for: eigen
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Of the top k /3 eigen vectors, those to which no gene had a maximal Pearson correlation were eliminated (for k = 120, only one eigen vector was eliminated in each cycle).
The remaining eigen vectors were used as prototype centroids for that clustering cycle.
To estimate the dependence of the procedure on the eigen vectors used to seed the clusters, a similar bootstrapping procedure was carried out in which PCA was performed on 4,373 genes chosen randomly from dataset B but the cluster refinement was done using all genes in dataset B. The frequency of each centroid was scored as described above.
More than 50% of the final centroids were identified in 90% of the bootstrapping trials in which PCA was performed on a random sample of the data, despite the fact the most of the eigen vectors were significantly different in each trial (see Materials and methods).
Most of the final centroids bore little similarity to the eigen vectors used to initialize the process, with less than 5% of final centroids similar to any of the eigen vectors with a Pearson correlation greater than 0.7.