Words similar to egr-
Example sentences for: egr-
How can you use “egr-” in a sentence? Here are some example sentences to help you improve your vocabulary:
AP-1 = activator protein-1; COL2A1 = procollagen 2 alpha 1; egr-1 = early growth response gene-1; ets = erythroblastosis gene twenty-six; IL-1β = interleukin-1β; LH = lactalbumin hydrolysate; LIF = leukemia inhibitory factor; MAPK= mitogen-activated protein kinase; MMP = matrix metalloproteinase; NF-κB = nuclear factor-κB; OA = osteoarthritis; PDGF = platelet-derived growth factor; RT-PCR = reverse transcriptase polymerase chain reaction; SMAD4 = mothers against dpp homolog 4; TGF-β = transforming growth factor-β.
The expression profiles for c-Jun and JunB were similar to the profile for egr-1, another immediate early gene in IL-1-stimulated chondrocytes [ 23].
The effects of PGs on cell proliferation and collagen production have been widely studied in different cell types [ 13 14 15 16 17 26 ] . TXA 2 has been studied extensively because of its apparent role in atherosclerosis, due to its prothrombotic and mitogenic activities on vascular smooth muscle cells [ 15 16 ] . These mitogenic effects are potentiated by growth factors [ 15 16 27 28 ] . In vascular smooth muscle cells TXA 2 stimulates synthesis of bFGF and increases the expression of the proto-oncogenes c-fos , c-myc , and egr-1 , which are associated with entry into the cell growth cycle [ 15 ] . In addition, TXA 2 increases proliferation of fibroblasts [ 13 ] and smooth muscle-like glomerular mesangial cells [ 14 ] .
egr-1 is an IL-1-inducible immediate early gene in chondrocytes [ 23] and has been implicated in the elevated MMP-1 gene expression observed in rheumatoid synoviocytes [ 33, 34].
However, when this gene was analyzed by RT-PCR, we found a robust increase in egr-1 mRNA within 1 hour of IL-1 stimulation, which declined significantly by 2 hours (Fig.
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