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Example sentences for: egr-

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The effects of PGs on cell proliferation and collagen production have been widely studied in different cell types [ 13 14 15 16 17 26 ] . TXA 2 has been studied extensively because of its apparent role in atherosclerosis, due to its prothrombotic and mitogenic activities on vascular smooth muscle cells [ 15 16 ] . These mitogenic effects are potentiated by growth factors [ 15 16 27 28 ] . In vascular smooth muscle cells TXA 2 stimulates synthesis of bFGF and increases the expression of the proto-oncogenes c-fos , c-myc , and egr-1 , which are associated with entry into the cell growth cycle [ 15 ] . In addition, TXA 2 increases proliferation of fibroblasts [ 13 ] and smooth muscle-like glomerular mesangial cells [ 14 ] .
egr-1 is an IL-1-inducible immediate early gene in chondrocytes [ 23] and has been implicated in the elevated MMP-1 gene expression observed in rheumatoid synoviocytes [ 33, 34].
The expression profiles for c-Jun and JunB were similar to the profile for egr-1, another immediate early gene in IL-1-stimulated chondrocytes [ 23].
However, when this gene was analyzed by RT-PCR, we found a robust increase in egr-1 mRNA within 1 hour of IL-1 stimulation, which declined significantly by 2 hours (Fig.
Surprisingly, egr-1 expression was increased only 1.3-fold in this Human Cancer 1.2 K array (data not shown).