Words similar to efflux
Example sentences for: efflux
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CHO.asbt cells produce recombinant asbt with a molecular mass and kinetic parameters that are similar to previously reported values [ 6 ] . It is not known if CHO cells have pathways capable of facilitating the efflux of bile acids out of the cell.
Since TNFRSF induces cell death by causing an efflux of glutathione (GSH) in other cell types [ 42 ] we sought to determine if pretreatment of CLENDO cells with GSH would attenuate lethality associated with TNFα treatment.
Efforts to identify alternative mechanisms for resistance may be guided by experience with imatinib resistance in the context of BCR-ABL, and should include full-length sequencing of EGFR to identify other resistance mutations, and analysis for evidence of gene amplification, as well as investigation of other well-characterized mechanisms of drug resistance such as drug efflux or increased drug metabolism.
Previous studies on human skin fibroblasts showed that MTX had no effect on [Ca 2+] i , vital dye uptake, or fura-2 efflux when the cells were challenged in the absence of extracellular Ca 2+[ 8].
There is a high degree of amino acid similarity among folate transporters and the thiamine transporter of the plasma membrane [ 7 8 9 10 ] . Recently, it was found that in murine cells there can be a substantial efflux of ThDP mediated by the reduced folate carrier protein [ 22 ] . GlyB cells are a Chinese hamster ovary cell line derivative that are deficient in the transport of folates into mitochondria, and the responsible mitochondrial transporter has recently been identified and its gene cloned [ 23 ] . We wondered if the mitochondrial folate transporter was responsible for uptake of ThDP into mitochondria, making analogies to the ability of the plasma membrane folate transporter being able to transport ThDP.