Words similar to efficacious
Example sentences for: efficacious
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5. When loop diuretics are used in the management of ARF, continuous infusion may be more efficacious than bolus administration in achieving diuresis.
Transportation difficulties, work-related demands, and regional differences in health care quality may also have impeded access to efficacious asthma care.
Our data clearly show that nalbuphine is a potent agonist at the μ opioid receptor with an efficacy similar to that of morphine, thus agreeing with in vivo data showing that morphine and nalbuphine are equally potent as analgesics [ 33 ] . However, other reports have described nalbuphine as a "mixed agonist/antagonist" with agonism at κ opioid receptors and antagonism at μ opioid receptors based on in vivo data [ 11 33 ] . This categorization is likely due to the fact that nalbuphine has been shown to reduce the ventilatory depressant effect of other opioids, while adding to their analgesic effect [ 33 ] . Nalbuphine is also used clinically to reduce the opioid-mediated side effects such as itching, without completely reversing the analgesic effects of the full agonists [ 34 35 36 ] . According to our data, although nalbuphine is clearly a potent agonist at μ receptors, its levels of agonism is significantly lower than the very efficacious drug fentanyl and the endogenous ligand β-endorphin.
However, in another study, butorphanol was reported to be equipotent in its antinociceptive effect to that of morphine [ 32 ] . In our assays, we have observed that butorphanol and morphine are equally efficacious in inhibiting cAMP production, although butorphanol is more potent than morphine in this assay.
Antagonists to 5-HT 3 Rs are clinically efficacious in the treatment of chemotherapy-induced emesis [ 15 ] and recent studies on human subjects have suggested their potential application in the treatment of early onset alcoholism [ 16 17 ] .
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