Words similar to effectors

Example sentences for: effectors

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By examining a range of subspaces, this analysis can be used to partition a transcription profile and define which effectors are responsible for particular patterns of expression.
Among beta-cell autoantigens, GAD65 is an important initial target of the immune response that results in beta-cell destruction and diabetes, in both humans and NOD mice [ 6 7 8 9 ] . While both humoral and cellular responses to GAD65 occur as early as 4 weeks of age in NOD mice [ 8 ] , there is considerable evidence that beta-cell-specific T H 1 cells are the effectors of T1DM, whereas T H 2 cells appear to have a protective role [ 10 ] . Accordingly, a shift of the autoimmune response from T H 1 to T H 2 predominance has represented a promising strategy for prevention of diabetes and other T H 1-mediated autoimmune diseases.
Insulin and IGF-I bind and stimulate tyrosine kinase receptors which interact with a large number of effectors [ 6 7 ] . Complex interactions occur between these two types of signaling pathways that are the subject of intense investigation.
We also found that while downstream effectors assemble onto the tyrosine phosphorylated Cas SD domain, the downstream signals were not activated.
Thus, both Th1 and Th2 effectors derived from DO11.hCARΔcyt mice are competent hosts for adenoviral transduction, and were equivalent to or better than naïve DO11.hCARΔcyt cells with respect to their transduction efficiencies and/or reporter expression levels.