Words similar to effector
Example sentences for: effector
How can you use “effector” in a sentence? Here are some example sentences to help you improve your vocabulary:
CD8 + cytolytic T lymphocytes (CTLs) are the primary effector cells of the adaptive immune system and have a major role in protecting us from a vast array of diseases including cancer.
Of the CD4 +T cells, 20 ± 3.6% and 16 ± 2.0% were effector memory cells in the SLE and healthy control groups ( n = 12 in each), respectively, and only a very small population of the cells were terminally differentiated effector memory CD4 +T cells in SLE patients (2.
COX-2 is an inducible enzyme upregulated in inflammatory states [ 20 21 ] . Notably, many NSCLC and what have been characterized as "premalignant" lung lesions have been shown to constitutively express the COX-2 enzyme and produce prostaglandin E-2 (PGE-2), the primary product of the COX-2 pathway [ 22 23 24 25 26 ] . Importantly, PGE-2 production by tumor cells has been linked to tumor-induced immunosuppression in NSCLC [ 2 3 4 5 ] . PGE-2 has been shown to directly suppress T cell mediated immunity, the primary effector against tumor cells, at a variety of levels [ 2 3 4 5 6 7 ] . Further, PGE-2 has been shown to induce the IL10 in mononuclear cells [ 4 5 ] . IL10 is a prominent immunosuppressive cytokine that may have a dominant role in preventing innate antitumor responses in the NSCLC environment [ 2 3 4 5 ] , [ 8 9 10 11 12 13 14 15 16 17 18 19 ] . Among myriad suppressive effects on T cells and antigen presenting cells, IL10 is known to inhibit IL12 production [ 14 15 16 17 18 ] . IL12 plays a key role in the initiation and potentiation of cellular immune responses and alteration of the IL12 producing function in circulating mononuclear phagocytes may be a critical factor in suppressed T cell immunity to NSCLC [ 27 28 ] .
Then we examined whether the combined effects of anti-IFN-γ antibody and IL-4 could influence the effector phenotype of cells isolated from the synovium.
Recently, memory CD8 +T cells were classified into three distinct populations, based on phenotype [ 9 10 11 ] : a central memory population, which is CD45RA -CCR7 +CD62L +CD28 +IL-2 +IFN-γ -; and two effector memory populations, namely the CD45RA -CD62L -CCR7 -and the terminally differentiated CD45RA +CD62L -CCR7 -populations.
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