Words similar to early-onset

Example sentences for: early-onset

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The DQA1*0501 allele is strongly associated with early-onset pauciarticular JRA in Northern European populations [ 23 24 ] and with increased risk for juvenile dermatomyositis [ 25 ] and Sjögren's syndrome with high autoantibody production [ 26 27 ] . In our proposed model, aberrant class II MHC regulation could result from altered DEK binding and/or interaction with NF-Y, and aberrant class II expression may alter or enhance reactivity against DEK-derived or other self peptides.
Immune dysregulation appears to play a key pathogenic role, as circulating autoantibodies are common in patients with certain JRA clinical subtypes [ 1 2 3 4 5 6 7 ] . Two recent studies have shown a highly significant association between early-onset pauciarticular JRA and circulating antibodies to the 43-kDa nuclear protein DEK [ 8 9 ] . Although circulating DEK antibodies have subsequently been found in children and adults with other autoimmune diseases [ 10 11 ] , these two studies did reveal that children with JRA are significantly more likely to have anti-DEK antibodies than are children without rheumatic disease.
PS1 is a gene involved in early-onset familial Alzheimer's disease.
Previous documentation by Scheimpflug analysis demonstrated that the annual expansion rate of the lenticular A-P length is accelerated 70% in early-onset diabetics [ 8 ] . Steepening of the anterior and posterior surface curvatures was detected but little difference in lens nuclear size was found.