Example sentences for: dynein

How can you use “dynein” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The AAA domain of midasin is evolutionarily related to that of dynein, but it appears to lack a microtubule-binding site.

  • Examples include light (post-Golgi protein trafficking), concertina (α-like G protein subunit), Nipped-B (morphogenesis), rolled (MAP kinase), poly(ADP-ribose) polymerase (chromatin structure), bobbed (ribosomal RNA), and the Y-linked fertility factors kl-2, kl-3 and kl-5 (dynein heavy chains) [ 33].

  • Such analysis of the AAA protomers that are best conserved among organisms (AAA2, AAA3, AAA4 and AAA5 in midasin, and AAA1 in dynein) shows that the AAA protomers of midasin and dynein are substantially more closely related to each other than they are to those in the other branches of the AAA family examined (Figs 7, 8).

  • Concomitant with this development of asymmetrical structure, the AAA1 protomer of the dynein motor unit evolved a functional dominance, in which it alone retains the full ability for binding and hydrolysis of ATP, while AAA2, AAA3 and AAA4 have lost the capability for hydrolysis and the most degenerate protomers AAA5 and AAA6 show no significant binding of ATP [ 20 21 22 ] . In midasin, the specialization of AAA protomers appears to have taken a less drastic course than in dynein.

  • This result supports the view that midasin and dynein evolved from a common AAA ancestral protein that had already developed a subunit structure of six AAA protomers in a single polypeptide.


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