Words similar to dynein
Example sentences for: dynein
How can you use “dynein” in a sentence? Here are some example sentences to help you improve your vocabulary:
Myosin, the actin motor protein, has an extended coiled-coil domain necessary for the assembly of the muscle thick filaments [ 7 ] . Kinesin and dynein, two microtubule motor proteins, also contain coiled-coil domains [ 8 9 ] .
Concomitant with this development of asymmetrical structure, the AAA1 protomer of the dynein motor unit evolved a functional dominance, in which it alone retains the full ability for binding and hydrolysis of ATP, while AAA2, AAA3 and AAA4 have lost the capability for hydrolysis and the most degenerate protomers AAA5 and AAA6 show no significant binding of ATP [ 20 21 22 ] . In midasin, the specialization of AAA protomers appears to have taken a less drastic course than in dynein.
The early evolutionary divergence of the different major branches of the AAA family makes it difficult to evaluate the phylogenetic relationships among them [ 45 ] . However, by restricting the analysis to residues in the more highly conserved regions of the AAA structure that interact directly with ATP, we have been able to improve the signal to noise ratio sufficiently to probe the phylogenetic relationship of midasin and dynein to representative members in other branches of the AAA family.
This result supports the view that midasin and dynein evolved from a common AAA ancestral protein that had already developed a subunit structure of six AAA protomers in a single polypeptide.
The ortholog in these species, as well as the presence of an unassembled orthologous gene in humans, Caenorhabditis and Giardia, has been noted by Mocz and Gibbons [ 6 ] , who discussed its evolutionary relationship to the heavy chain of dynein motor protein.
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