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Example sentences for: dwnt

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Several genes expressed specifically in the normal male foreskin fibroblasts have been previously implicated in male genital development, including HOXA13 , the T-box genes, BMP4 and DWnt2 . Mutations in HOXA13 can cause distal limb and urogenital-tract malformations such as male hypospadias in hand-foot-genital syndrome [ 21 ] . T-box genes ( TBX ) are essential early regulators of limb development and also appear to be involved in male genital development [ 22 23 ] . Mutations in TBX3 cause the ulnar-mammary syndrome characterized by limb, apocrine, and genital developmental abnormalities [ 23 ] . Expression of T-box genes 2, 3, and 5 was significantly higher in normal male foreskin fibroblasts than in AIS genital fibroblasts.
BMP4 has been implicated in ductal budding and branching during prostate development [ 24 ] and a potential role of BMP4 in external genital development has also been postulated [ 25 ] . DWnt2 has been found to have roles in sex-specific cell determination in the gonads and genital disc of Drosophila [ 26 ] . Thus, mutations in genes characteristically expressed in normal male foreskin fibroblasts can, in some cases, lead to defective genital development.