Words similar to ductal
Example sentences for: ductal
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Female mice harboring the Wnt-1 transgene develop extensive mammary hyperplasia early in life, and 50% of them develop mammary ductal carcinomas by 6 months of age [ 27].
A recent study confirms this to be the case in breast cancer, where expression of TSP-1 in stroma adjacent to ductal carcinoma in situ is lost in cases with more aggressive histological features [ 30 ] . There are also reports, however, that fibroblast TSP-1 can induce matrix metalloproteinase-9 in breast tumor cells and gastric cancer tumor cells, and this in turn may lead to a more invasive phenotype [ 14 31 ] . In the present study, TSP-1 was not expressed differentially in the stroma of benign tissue specimens or malignant tissue specimens, nor in the epithelial component of breast tumors with or without metastases.
By 12 weeks of treatment, all three chemopreventive agents had a significant effect on glandular histology, with tamoxifen and 9cRA showing the greatest suppression of ductal development and lobule formation, and 4-HPR showing a relatively mild effect.
The four additional FFPE archived ductal carcinomas and the matched nodal metastases ( n = 8) were stained with the aforementioned antibodies using the antigen retrieval method now described to assess the utility of the antibodies on archived tissues.
Results showed that all three cases spanned a morphologic spectrum ranging from columnar cell hyperplasia to ductal carcinoma in situ . Case 1 (columnar cell hyperplasia) contained two ducts of interest lined by about 500 epithelial cells surrounded by morphologically distinct ME cell layers on the H&E-stained section (Fig.