Example sentences for: downstream

How can you use “downstream” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Activation of the JNK pathway can lead to the phosphorylation of downstream members including c-jun that belongs to the AP-1 transcription factor family [ 12 52 ] . Because results from this study indicated that JNK pathway was activated by 25-OH-cholesterol, one could expect that AP-1 would be activated in cells treated with cholesterol oxides.

  • These systemic effects have downstream repercussions, only a few of which were reflected in changes in gene expression at the tumor site.

  • This occurs when an L1 transcript reads into a portion of the downstream flanking sequence.

  • The region upstream of aa 215 and downstream of aa 329 were not required for binding BTBD2 (Fig.

  • Beta-catenin then accumulates in the nucleus where it interacts with its transcriptional co-activators, members of the Lymphoid Enhancer Factor/T Cell Factor (LEF/TCF) family of high mobility group DNA binding proteins to regulate gene expression [ 1 ] . Many downstream gene targets of the canonical Wnt/beta-catenin pathway have been identified http://www.stke.org.


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