Example sentences for: downstream

How can you use “downstream” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A proposed consequence of L1 3' transduction is exon shuffling [ 28 33 34 ] . That is, an exon downstream of an L1 may be co-mobilized with that same L1 and inserted at a new locus such that the exon is integrated into another gene.

  • To determine if this dramatically decreased EGFR expression could inhibit downstream components of EGF signaling, we also examined activation of ERK1 (a terminal effector in the mitogen activated protein kinase pathway).

  • Heart and skeletal muscle share many key gene regulatory factors and downstream genetic programs, and the loss of a few key negative regulatory checkpoints might allow the cells to differentiate towards a cardiac phenotype.

  • It is also possible that the alternative mechanism is due to phosphorylation of cPLA 2 on a novel site by a kinase that is downstream of the MEK1/ERK pathway or phosphorylation of a regulatory protein.

  • Marked variation exists in both the primary sex determination signal and in the downstream genetic pathways that interpret the signal.


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