Words similar to dose-dependent
Example sentences for: dose-dependent
How can you use “dose-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:
Intra-articular TGF-β1 expression resulted in dose-dependent biological effects in the rabbit knee as well as in adjacent muscle.
However, rapamycin abolished the insulin-mediated inhibition of SP-A gene expression in a dose-dependent manner.
Overall trends (from current to former to never smokers) were present for alcohol use, triglycerides, total cholesterol, and HDL cholesterol, as shown in Figure 2. In models fully adjusted for all covariates (not shown), dose-dependent associations persisted for HDL cholesterol and triglycerides ( p ≤ 0.01).
The effect of IFN-γ is dose-dependent [ 26, 27], and different concentration ranges have been shown [ 28] to allow rapid progress through the acute infection cycle (low IFN-γ concentration), to promote a stable state of persistence (medium IFN-γ concentration), or to completely resolve the infection (high IFN-γ concentration).
The available research regarding cognitive function and phytoestrogens suggests that large amounts of phytoestrogens, consumed as tofu, have an adverse influence on cognitive ability in men, where decreased brain weight, increased ventricular size and dementia have been reported [ 44 ] . In ovariectomized female rats, on the other hand, phytoestrogen treatments resulted in a dose-dependent improvement of VSM [ 45 ] . This improvement in cognitive ability in phytoestrogen treated females may be due in part to the increased presence of choline acetyltransferase messenger RNA in the frontal cortex, which has been shown to be associated with protection and enhancement of cognitive function [ 45 ] . Furthermore, we have shown that phytoestrogens significantly affect the brain calcium-binding protein calbindin (CALB), which acts as a buffer by binding intracellular calcium and plays an important role in mediating cell proliferation, programmed cell death (apoptosis), and neurotoxicity [ 48 49 50 51 52 ] . This neuroprotective mechanism via CALB appears to be important in neurological disorders such as Parkinson's disease and Huntington's disease [ 48 49 50 51 52 ] . Additionally, Cyclooxygenase-2 (COX-2) seems to play an important role in mediating functional neuronal maturation and responses to certain stimuli in the brain [ 53 54 55 ] . The expression of COX-2 is associated with key pathophysiologic events in Alzheimer's disease: deposition of beta-amyloid protein in neuritic plaques within the hippocampus and cortex [ 53 54 55 ] . Of particular importance to this study is the fact that COX-2 has been shown to be influenced by steroidal hormones [ 53 54 55 ] . Therefore, the expression of COX-2 in the frontal cortex may also be hormonally regulated and relevant to cognitive decline.
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