Words similar to dose-dependent
Example sentences for: dose-dependent
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PG E 2 addition resulted in a dose-dependent increase in the appearance of macroscopic foci, with visible foci appearing at 1 ng/ml (3 nM) and becoming abundant at 10 ng/ml (30 nM) (Fig.
The available research regarding cognitive function and phytoestrogens suggests that large amounts of phytoestrogens, consumed as tofu, have an adverse influence on cognitive ability in men, where decreased brain weight, increased ventricular size and dementia have been reported [ 44 ] . In ovariectomized female rats, on the other hand, phytoestrogen treatments resulted in a dose-dependent improvement of VSM [ 45 ] . This improvement in cognitive ability in phytoestrogen treated females may be due in part to the increased presence of choline acetyltransferase messenger RNA in the frontal cortex, which has been shown to be associated with protection and enhancement of cognitive function [ 45 ] . Furthermore, we have shown that phytoestrogens significantly affect the brain calcium-binding protein calbindin (CALB), which acts as a buffer by binding intracellular calcium and plays an important role in mediating cell proliferation, programmed cell death (apoptosis), and neurotoxicity [ 48 49 50 51 52 ] . This neuroprotective mechanism via CALB appears to be important in neurological disorders such as Parkinson's disease and Huntington's disease [ 48 49 50 51 52 ] . Additionally, Cyclooxygenase-2 (COX-2) seems to play an important role in mediating functional neuronal maturation and responses to certain stimuli in the brain [ 53 54 55 ] . The expression of COX-2 is associated with key pathophysiologic events in Alzheimer's disease: deposition of beta-amyloid protein in neuritic plaques within the hippocampus and cortex [ 53 54 55 ] . Of particular importance to this study is the fact that COX-2 has been shown to be influenced by steroidal hormones [ 53 54 55 ] . Therefore, the expression of COX-2 in the frontal cortex may also be hormonally regulated and relevant to cognitive decline.
The activation of flank marking is dose-dependent, and specific to AVP, as microinjections of other neuropeptides, excitatory amino acids, and catecholamines do not elicit the behavior [ 1 2 6 ] . Flank marking is also specific to AVP V1 receptors, as the behavior is selectively inhibited by V 1 receptor antagonists and activated by V1 receptor agonists [ 4 5 ] .
Sleep loss from a baseline of 7.7 h was associated with a dose-dependent increase in BMI.
A dose-dependent effect of Smad1 on receptor-induced degradation of SNIP1 was observed (Fig.
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