Words similar to domoic

Example sentences for: domoic

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The results of this study demonstrated that even though the highest concentration of domoic acid tested, namely 1 mM, did not affect rat neonatal microglia viability in vitro, domoic acid concentrations as low as 10 μM were clearly cytotoxic to cerebellar granule neurons after a 6 hour exposure.
To rule out the possibility that domoic acid might have degraded as a consequence of either our preparative method or the subsequent freezing (-80°C) and thawing of the domoic acid stock solution, electrospray mass spectrometry was run on both the domoic acid stock solution (12.
This concept is supported by the established fact that glutamate receptors are highly conserved between mammals [ 26 ] . Ultimately studies contributing to the characterization of the early biochemical as well as cellular events subsequent to an intoxication with the marine toxin domoic acid will yield new insights for the rationale development of novel therapeutic interventions for the prevention and treatment of amnesic shellfish poisoning.
Determination of domoic acid by electrospray mass spectrometry
For the O 2 - assay, rat neonatal microglia (250,000 cells/ 24-well cell culture clusters) were treated with (1) 1 mM domoic acid, (2) LPS-free water used as a vehicle for domoic acid or (3) 10 ng/ml LPS in a final volume of 1 ml of DMEM supplemented with 10% FBS + 120 U/ml P + 12 μg/ml S and incubated in a humidified 5% CO 2 incubator at 36°C for 1 to 6 hours.