Example sentences for: dlg
How can you use “dlg” in a sentence? Here are some example sentences to help you improve your vocabulary:
The DLG5 gene encodes for 2 PDZ domains, with another region in the N-terminus having very weak homology to an additional two PDZ domains.
The DLG5 gene encodes for a protein that is a member of the MAGUK (Membrane Associated Guan late Kinase homologs) family of proteins located in the plasma membrane [ 2 ] . MAGUK is a new family of proteins that act as a molecular scaffold for intracellular signaling pathways [ 11 ] . The MAGUK family of proteins is characterized by domains that interact with other proteins to create an assembly of large multi-protein complexes [ 10 ] . The PDZ (PSD-95, DLG and ZO-1) domains are the best characterized for their binding to the C-terminal region of channels and transmembrane proteins [ 11 ] . Usually each protein has 1-3 copies of such domains [ 8 12 13 ] . The SH3 domain (Src homology 3) are present in proteins that couple transmembrane receptors to signaling molecules [ 14 ] . The presence of this domain in MAGUKs increases their possibilities of interacting with signaling pathways.
The exons and flanking intronic sequences of DLG50 were amplified by PCR and sequenced in four members of the family, two affected and two normals.
Exclusion of a deletion from the haploid cell lines confirmed the absence of any mutation and thus, DLG5 was excluded as a cause for the atrial fibrillation in these families.
Two distinct transcripts of DLG5 were observed differing by only 12 bp, which would predict the addition (or deletion) of 4 amino acids, but would not alter the translation frame of the gene.
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