Example sentences for: dlg
How can you use “dlg” in a sentence? Here are some example sentences to help you improve your vocabulary:
We then performed PCR using primers anchored in the introns of DLG5 for each of the exons on both the normal haploid DNA and the disease bearing haploid DNA.
It is notable that the PDZ domains predicted for the DLG5 protein do not have the GLGF motif [ 2 ] , present in most members of the MAGUK family.
The DLG5 gene encodes for a protein that is a member of the MAGUK (Membrane Associated Guan late Kinase homologs) family of proteins located in the plasma membrane [ 2 ] . MAGUK is a new family of proteins that act as a molecular scaffold for intracellular signaling pathways [ 11 ] . The MAGUK family of proteins is characterized by domains that interact with other proteins to create an assembly of large multi-protein complexes [ 10 ] . The PDZ (PSD-95, DLG and ZO-1) domains are the best characterized for their binding to the C-terminal region of channels and transmembrane proteins [ 11 ] . Usually each protein has 1-3 copies of such domains [ 8 12 13 ] . The SH3 domain (Src homology 3) are present in proteins that couple transmembrane receptors to signaling molecules [ 14 ] . The presence of this domain in MAGUKs increases their possibilities of interacting with signaling pathways.
Cloning and sequencing of the DLG5 cDNA
Thus, DLG50 is excluded as a possible cause of familial atrial fibrillation in these families.