Words similar to distantly
Example sentences for: distantly
How can you use “distantly” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, we also performed comparisons for pairs of orthologous proteins identified between the more distantly related S. cerevisiae and C. elegans [ 6 ] and no significant relationship between evolutionary rates and protein-protein interactions was observed (data not shown).
They contain a distinct carboxy-terminal globular domain that is distantly related to the SWIRM domain, suggesting that this domain could mediate a subset of their interactions with the transcriptional machinery.
The presence of considerable sequence conservation in more distantly related isolates rather than among close relatives, combined with the observations stated above, is a pattern consistent with the potential plasmid location of these sequences.
Figure 1shows that there is a remnant of gene order conservation even between distantly related organisms, in both the Bacteria and the Archaea.
This approach had been pioneered in the classical work of Dobzhansky and Sturtevant who used inversions in Drosophila chromosomes to construct an evolutionary tree [ 12 ] . Subsequently, mathematical methods have been developed to calculate rearrangement distances between genomes, and, using these, phylogenetic trees have been built for certain small genomes, such as plant mitochondria and herpesviruses [ 13 14 ] . These approaches, however, are applicable only to genomes that show significant conservation of global gene order, which is manifestly not the case among prokaryotes [ 15 16 17 ] . Even relatively close species such as, for example, Escherichia coli and Haemophilus influenzae, two species of the γ-subdivision of Proteobacteria, retain very little conservation of gene order beyond the operon level (typically, two-to-four genes in a row), and essentially none is detectable among evolutionarily distant bacteria and archaea [ 15 16 18 ] . Very few operons, primarily those coding for physically interacting subunits of multiprotein complexes such as certain ribosomal proteins or RNA-polymerase subunits, are conserved across a wide range of prokaryotic lineages [ 15 16 ] . On the other hand, pairwise comparisons of even distantly related prokaryotic genomes reveal considerable number of shared (predicted) operons, which creates an opportunity for a meaningful comparative analysis [ 19 ] [ 20 21 ] .
Loading...