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Example sentences for: dispensable
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2) There may be a hierarchy from "most-dispensable-to-least dispensable" substrate utilization for both carbon and nitrogen molecules.
For instance, they are dispensable for DNA damage-dependent activation of the Rad26/Rad3-kinase complex [ 18 ] , but are required for the Rad3-dependent phosphorylation of Chk1 [ 23 ] . Structural predictions of Hus1, Rad1 and Rad9 have led to the proposal that all three fold similarly to the subunits of Proliferating Cell Nuclear Antigen (PCNA) [ 24 25 26 ] . Consistent with these predictions, PCNA exists as a homotrimer [ 27 ] while Hus1, Rad1 and Rad9 all interact and possibly form a heterotrimer [ 25 28 ] . In addition, Rad17 has sequence similarity and physical interactions with subunits of Replication Factor C (RFC) [ 29 30 ] . Based on the RFC-PCNA paradigm, the Rad17-RFC complex may load the PCNA-like Rad9-Rad1-Hus1 (9-1-1) complex onto genomic lesions discovered by the Rad26/Rad3 complex.
Of the sixteen U3 gene trap proviruses selected in ES cells that we have introduced into the germline, six resulted in obvious phenotypes (typically embryonic death) when bred to homozygosity [ 10 21 28 29 30 31 32 ] . In cases where no obvious phenotypes are observed, it is important to determine if the insert did not disrupt gene expression or if the gene is dispensable.
We mentioned the name of a dispensable subassistant to the deputy assistant editor in our Bogotá bureau.
A surprising finding of this study was that the F-box of Pop2p is dispensable for Rum1p degradation and ploidy control, while the F-box of Pop1p is essential for both functions (Fig.
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