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Example sentences for: dispensable
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A surprising finding of this study was that the F-box of Pop2p is dispensable for Rum1p degradation and ploidy control, while the F-box of Pop1p is essential for both functions (Fig.
It is dispensable for chromosome pairing and synapsis in some organisms, but is required in others [ 22 24 25 26 27 28 ] . Budding yeast spo11Δ (null) mutants lack chromosome pairing, but catalytic site tyrosine mutants ( spo11-Y135F ) support significant levels of DSB-independent pairing [ 29 ] , so the function of Spo11 proteins in pairing may be separable from its function in catalyzing recombination.
For instance, they are dispensable for DNA damage-dependent activation of the Rad26/Rad3-kinase complex [ 18 ] , but are required for the Rad3-dependent phosphorylation of Chk1 [ 23 ] . Structural predictions of Hus1, Rad1 and Rad9 have led to the proposal that all three fold similarly to the subunits of Proliferating Cell Nuclear Antigen (PCNA) [ 24 25 26 ] . Consistent with these predictions, PCNA exists as a homotrimer [ 27 ] while Hus1, Rad1 and Rad9 all interact and possibly form a heterotrimer [ 25 28 ] . In addition, Rad17 has sequence similarity and physical interactions with subunits of Replication Factor C (RFC) [ 29 30 ] . Based on the RFC-PCNA paradigm, the Rad17-RFC complex may load the PCNA-like Rad9-Rad1-Hus1 (9-1-1) complex onto genomic lesions discovered by the Rad26/Rad3 complex.
[The Times, 20 June 1988] There is probably something to be said in favour of the occasional use of rude language in drama for the sake of realism; on the other hand, in the real world rude language is often the resort of those who are unable to articulate their thoughts and emotions, and the presence of characters so afflicted is certainly dispensable in drama.
Of the sixteen U3 gene trap proviruses selected in ES cells that we have introduced into the germline, six resulted in obvious phenotypes (typically embryonic death) when bred to homozygosity [ 10 21 28 29 30 31 32 ] . In cases where no obvious phenotypes are observed, it is important to determine if the insert did not disrupt gene expression or if the gene is dispensable.
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