Example sentences for: dispensable

How can you use “dispensable” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 2) There may be a hierarchy from "most-dispensable-to-least dispensable" substrate utilization for both carbon and nitrogen molecules.

  • This suggests that MYOC haploinsufficiency is not causative for glaucoma and that myocilin may even be dispensable or redundant in normal human development or only important when ocular stress occurs.

  • The Pop2p F-box is unlikely to be a degenerate, non-functional, and hence dispensable, motif, as it carries all signature residues of the F-box (Fig.

  • For instance, they are dispensable for DNA damage-dependent activation of the Rad26/Rad3-kinase complex [ 18 ] , but are required for the Rad3-dependent phosphorylation of Chk1 [ 23 ] . Structural predictions of Hus1, Rad1 and Rad9 have led to the proposal that all three fold similarly to the subunits of Proliferating Cell Nuclear Antigen (PCNA) [ 24 25 26 ] . Consistent with these predictions, PCNA exists as a homotrimer [ 27 ] while Hus1, Rad1 and Rad9 all interact and possibly form a heterotrimer [ 25 28 ] . In addition, Rad17 has sequence similarity and physical interactions with subunits of Replication Factor C (RFC) [ 29 30 ] . Based on the RFC-PCNA paradigm, the Rad17-RFC complex may load the PCNA-like Rad9-Rad1-Hus1 (9-1-1) complex onto genomic lesions discovered by the Rad26/Rad3 complex.

  • It is dispensable for chromosome pairing and synapsis in some organisms, but is required in others [ 22 24 25 26 27 28 ] . Budding yeast spo11Δ (null) mutants lack chromosome pairing, but catalytic site tyrosine mutants ( spo11-Y135F ) support significant levels of DSB-independent pairing [ 29 ] , so the function of Spo11 proteins in pairing may be separable from its function in catalyzing recombination.


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