Words similar to disorganization
Example sentences for: disorganization
How can you use “disorganization” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, Müller points to structural studies that seem to uphold his theory of overall disorganization of the brain's cortex.
At some locations, however, there was retinal dysplasia or disorganization of photoreceptor position.
is expressed in skeletal muscle, with a less abundant ~7 kb transcript expressed in both skeletal and cardiac muscle [ 8 ] . Whereas tropomodulins or the Arp 2/3 complex cap the pointed end of actin filaments, the barbed end can be capped by CapZ, α, β, and γ adducins as well as gelsolin [ 9 10 11 ] . Control of thin filament length is critical for maintaining proper sarcomere function and length [ 12 ] . Inhibition of Tmod1's capping activity - either by using an antibody to its C-terminal end or by decreasing expression using an antisense Tmod1 transcript - results in elongated thin filaments and decreased cardiac contractility [ 13 14 ] . Tmod1 overexpression in rat cardiomyocytes causes shortening of the thin filaments and sarcomere disorganization, resulting in myofibril degeneration [ 14 ] . Likewise, mice overexpressing TMOD1 in the heart show disrupted sarcomere organization with shortened thin filaments, leading to myofibril degeneration and dilated cardiomyopathy [ 15 ] . Recently, Littlefield and colleagues showed that overexpression of GFP-Tmod1 in chick cardiac myocytes results in shortening of thin filaments; the authors proposed that excess Tmod1 decreases the affinity between actin monomers and pointed ends, leading to monomer dissociation and filament shortening [ 42 ] . Mutations in many proteins making up the cardiac sarcomere have been shown to cause cardiac hypertrophy [ 16 17 18 19 ] :mutations in the TPM1 gene, for example, cause type 3 familial hypertrophic cardiomyopathy (CMH3), and a transgenic mouse expressing a CMH3 mutation develops ventricular myocyte disarray and hypertrophy [ 20 ] . Mutations in myosin heavy chain 7 are estimated to account for 40-50% of the cases of hypertrophic cardiomyopathy [ 21 ] .
The critics gripe a bit but still give a standing ovation to Mike Leigh's ( Secrets and Lies ) new film, about a short span in the lives and work of Gilbert and Sullivan as they compose and stage The Mikado . "Only a lunatic would call Topsy-Turvy , with its lame first hour and host of loose ends, a masterpiece, but by the finale I was ready to have myself committed" (David Edelstein, Slate ). It's "one of those films that create a mix of erudition, pageantry and delectable acting opportunities, much as Shakespeare in Love did last year," and it "vigorously and amusingly explore[s] what it means for an artist to renew his energies by returning to square one" (Janet Maslin, the New York Times ). Several note its slow start and general disorganization: "[I]t teases us with the feeling that Leigh had a basic plan for the picture and never realized it" (Stanley Kauffmann, the New Republic ). (Click to read the rest of Edelstein's review in
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