Example sentences for: disorganization

How can you use “disorganization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The critics gripe a bit but still give a standing ovation to Mike Leigh's ( Secrets and Lies ) new film, about a short span in the lives and work of Gilbert and Sullivan as they compose and stage The Mikado . "Only a lunatic would call Topsy-Turvy , with its lame first hour and host of loose ends, a masterpiece, but by the finale I was ready to have myself committed" (David Edelstein, Slate ). It's "one of those films that create a mix of erudition, pageantry and delectable acting opportunities, much as Shakespeare in Love did last year," and it "vigorously and amusingly explore[s] what it means for an artist to renew his energies by returning to square one" (Janet Maslin, the New York Times ). Several note its slow start and general disorganization: "[I]t teases us with the feeling that Leigh had a basic plan for the picture and never realized it" (Stanley Kauffmann, the New Republic ). (Click to read the rest of Edelstein's review in

  • is expressed in skeletal muscle, with a less abundant ~7 kb transcript expressed in both skeletal and cardiac muscle [ 8 ] . Whereas tropomodulins or the Arp 2/3 complex cap the pointed end of actin filaments, the barbed end can be capped by CapZ, α, β, and γ adducins as well as gelsolin [ 9 10 11 ] . Control of thin filament length is critical for maintaining proper sarcomere function and length [ 12 ] . Inhibition of Tmod1's capping activity - either by using an antibody to its C-terminal end or by decreasing expression using an antisense Tmod1 transcript - results in elongated thin filaments and decreased cardiac contractility [ 13 14 ] . Tmod1 overexpression in rat cardiomyocytes causes shortening of the thin filaments and sarcomere disorganization, resulting in myofibril degeneration [ 14 ] . Likewise, mice overexpressing TMOD1 in the heart show disrupted sarcomere organization with shortened thin filaments, leading to myofibril degeneration and dilated cardiomyopathy [ 15 ] . Recently, Littlefield and colleagues showed that overexpression of GFP-Tmod1 in chick cardiac myocytes results in shortening of thin filaments; the authors proposed that excess Tmod1 decreases the affinity between actin monomers and pointed ends, leading to monomer dissociation and filament shortening [ 42 ] . Mutations in many proteins making up the cardiac sarcomere have been shown to cause cardiac hypertrophy [ 16 17 18 19 ] :mutations in the TPM1 gene, for example, cause type 3 familial hypertrophic cardiomyopathy (CMH3), and a transgenic mouse expressing a CMH3 mutation develops ventricular myocyte disarray and hypertrophy [ 20 ] . Mutations in myosin heavy chain 7 are estimated to account for 40-50% of the cases of hypertrophic cardiomyopathy [ 21 ] .

  • At some locations, however, there was retinal dysplasia or disorganization of photoreceptor position.

  • For example, Müller points to structural studies that seem to uphold his theory of overall disorganization of the brain's cortex.


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