Example sentences for: discontinuation

How can you use “discontinuation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • No drug interaction resulted in an adverse event or discontinuation of therapy.

  • Of note, the 3 patients who did not reach LDL cholesterol goal were not those who experienced side effects requiring discontinuation of therapy.

  • Study discontinuation in the repeated interruptions arm was due to protocol violation ( n = 1; patient restarted therapy during interruption out of protocol), loss to follow-up ( n = 1; patient imprisoned), and virological failure during on-therapy period ( n = 1; further discussed below).

  • On day zero (24 h) after discontinuation of Aza/MMF), blood samples were collected at time zero (baseline) and 12 h after the administration of TAC for lymphocyte proliferation and cytokine expression at the gene and protein level.

  • Sulfasalazine (SSZ) is a widely used and highly effective anti-inflammatory agent in the treatment of Crohn's disease and ulcerative colitis [ 1 2 3 ] . SSZ is also being used with increasing frequency in the treatment of various rheumatolgical disorders [ 4 5 6 7 ] . SSZ is preferred over other agents such as gold and penicillamine in rheumatology patients due to its more favorable side effect profile [ 8 9 10 ] . Nonetheless, rash, fever, and dyspepsia occur in 3% to 20% of treated patients [ 7 11 12 ] . These reactions are usually dose dependent and improve with dose reduction or discontinuation [ 7 12 ] . However, more serious but less common side effects have also been reported [ 13 14 15 16 17 18 19 ] . We now report a severe systemic reaction to SSZ in a 21-year-old female with rheumatoid arthritis characterized by granulomatous infiltration of the bone marrow, colon and small bowel as well as cholestatic hepatitis and seizures.


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