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Example sentences for: directional
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Of the 6,525 human and 566 mouse EST libraries considered, 899 and 176, respectively, had an LQS of greater than 0.95, indicating that these libraries were generated by an efficient method of directional cloning.
For example, a substantial fraction of publicly available ESTs were generated by a random priming method that provides no information about directionality of transcription [ 16], whereas other methods that exploit the 3' polyadenylated tails of eukaryotic mRNAs do provide directional information.
This correlation is fully consistent with the hypothesis that directional epistasis depends on the location of the reference sequence relative to other high-fitness genotypes.
The first physical step in directional motility is the extension of cellular processes termed pseudopods [ 11 ] . Pseudopodia are flattened, fan shape cellular protrusions enriched in signaling molecules and cytoskeletal elements including filamentous actin, which is preferentially nucleated at the leading edge of a migrating cell [ 12 ] . A key candidate for regulation of the T lymphocyte actin cytoskeleton is the GTP-binding protein Rho.
We assumed that if a gene was not subject to a systematic change in expression level, an observed directional change in a given mutant strain would occur randomly and independently with probability equal to the overall proportion of directional changes observed in that mutant strain.
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