Example sentences for: diamide

How can you use “diamide” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • By crosslinking protein sulfhydryl groups, diamide is thought to disrupt protein structure and trigger oxidative stress [ 57, 58], both of which are likely to perturb normal ER functions [ 59].

  • When the experiment clustering was performed on the basis of genes encoding protein-folding chaperones (the top 10 genes in cluster 11), a striking similarity between the effects of diamide and heat shock was observed (Figure 8b).

  • Roughly 40% (14/36) of the top characterized genes associated with this group encode protein-folding chaperones localized to different subcellular regions (including those that encode the cytosolic Hsp90 and Hsp70 factors, the mitochondrial Hsp10/Hsp60p and Ssc1p, and the ER- and mitochondrial-associated Ssa1p), and their induction following heat shock and diamide treatment is likely to be in response to widespread protein unfolding inflicted by these conditions.

  • That the effects of diamide were similar to those of different environmental conditions depending on the genes analyzed reflects the diverse effects of this drug on the cell (Figure 8f).

  • In terms of the genes induced in the UPR (identified as the top 30 genes or so in cluster 58), the effects of diamide were most similar to those triggered by the reducing agent DTT (Figure 8d).


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