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Example sentences for: diamide

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Roughly 40% (14/36) of the top characterized genes associated with this group encode protein-folding chaperones localized to different subcellular regions (including those that encode the cytosolic Hsp90 and Hsp70 factors, the mitochondrial Hsp10/Hsp60p and Ssc1p, and the ER- and mitochondrial-associated Ssa1p), and their induction following heat shock and diamide treatment is likely to be in response to widespread protein unfolding inflicted by these conditions.
In contrast to this relationship, when the experiment clustering was performed on genes encoding ER-resident proteins, the effects of zinc starvation were most similar to those inflicted by DTT and diamide (Figure 8d), suggesting that zinc limitation may initiate the UPR.
When the experiment clustering was performed on the basis of genes encoding protein-folding chaperones (the top 10 genes in cluster 11), a striking similarity between the effects of diamide and heat shock was observed (Figure 8b).
In terms of the genes induced in the UPR (identified as the top 30 genes or so in cluster 58), the effects of diamide were most similar to those triggered by the reducing agent DTT (Figure 8d).
In contrast, when the microarray clustering was performed on the basis of genes involved in oxidative stress defense, (the top 24 genes belonging to cluster 4), diamide was most similar to hydrogen peroxide and menadione, which inflict oxidative damage by generating reactive oxygen species (Figure 8c).