Example sentences for: dff

How can you use “dff” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The enhanced caspase 3 activity in BRCA1+ cells was clearly functional and resulted in increased proteolysis of downstream targets of caspase 3. That is, we found 40% less full length DFF45 at 1 h and 42% less at 1.5 h in BRCA1+ cells compared with BRCA1wt cells.

  • In BRCA1wt cells, the levels of full length DFF45 were 95% of control at 0.5 h, 40% of control at 1 h, and 22% of control at 1.5 h.

  • In contrast, in BRCA1+ cells, full length DFF45 was only 71% of control at 0.5 h, 16% of control at 1 h, and 10% of control at 1.5 h (Table 1).

  • As with DFF45, PARP cleavage was significantly enhanced in BRCA1+ cells suggesting that decreased DNA repair capacity in BRCA1+ cells may, in part, be due to premature inactivation of PARP.

  • This mutation, common among families with hereditary ovarian cancer, is a frameshift mutation occurring at the beginning of the C 3 HC 4 region of exon 2 that essentially interrupts RING domain function [ 19 29 30 ] . The results showed that disruption of the BRCA1 amino-terminal RING domain altered caspase 3 activation and subsequent DFF45 and PARP cleavage, resulting in accelerated STS-induced apoptosis.


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