Example sentences for: dff

How can you use “dff” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This mutation, common among families with hereditary ovarian cancer, is a frameshift mutation occurring at the beginning of the C 3 HC 4 region of exon 2 that essentially interrupts RING domain function [ 19 29 30 ] . The results showed that disruption of the BRCA1 amino-terminal RING domain altered caspase 3 activation and subsequent DFF45 and PARP cleavage, resulting in accelerated STS-induced apoptosis.

  • Degradation of full length DFF45 was used to indicate caspase 3 activity.

  • In BRCA1wt cells, the levels of full length DFF45 were 95% of control at 0.5 h, 40% of control at 1 h, and 22% of control at 1.5 h.

  • To determine whether elevated levels of cleaved caspase 3 resulted in increased cleavage of caspase 3 substrates, DFF45 cleavage was studied (Figure 3).

  • Instead, this amino-terminal mutation favored elevated caspase 3 levels that subsequently facilitated enhanced apoptosis by inactivating the caspase-dependent DNA repair proteins PARP and by inactivating DFF45, an inhibitor of the caspase-dependent DNase, DFF40.


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