Words similar to dff

Example sentences for: dff

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Polyclonal antibodies to caspase 3, caspase 9, and PARP were purchased from Cell Signaling (Beverly, MA), a monoclonal antibody to caspase 7 and a polyclonal antibody to DFF45 were obtained from BD Transduction (San Diego, CA).
To determine whether elevated levels of cleaved caspase 3 resulted in increased cleavage of caspase 3 substrates, DFF45 cleavage was studied (Figure 3).
In contrast, in BRCA1+ cells, full length DFF45 was only 71% of control at 0.5 h, 16% of control at 1 h, and 10% of control at 1.5 h (Table 1).
This mutation, common among families with hereditary ovarian cancer, is a frameshift mutation occurring at the beginning of the C 3 HC 4 region of exon 2 that essentially interrupts RING domain function [ 19 29 30 ] . The results showed that disruption of the BRCA1 amino-terminal RING domain altered caspase 3 activation and subsequent DFF45 and PARP cleavage, resulting in accelerated STS-induced apoptosis.
Disruption of this domain triggered an elevated caspase 3-dependent apoptotic response and affected downstream proteins such as DFF45 and PARP.