Words similar to developmentally
Example sentences for: developmentally
How can you use “developmentally” in a sentence? Here are some example sentences to help you improve your vocabulary:
Analysis of non-coding sequence evolution reveals that levels of conservation vary with divergence time, and that conserved non-coding sequences (CNCSs) exhibit a striking pattern of spatial clustering in Drosophila . Using transgenic reporter assays we show that CNCS clusters can be used to accurately predict a developmentally regulated enhancer in the apterous ( ap ) region.
It is intriguing to note that reduced BrdU incorporation is particularly detected in developmentally older animals where the vertebral centers are made up of a larger number of cells, reflecting a longer duration since commitment of the precursors to chondrocyte fate.
[ 17 ] have established that silymarin can compete with estradiol at estradiol receptor binding sites [ 17 ] . Therefore, it is possible that the ameliorative effects of SY observed in the present study can be attributed to estrogen receptor activation at developmentally appropriate times.
Surfactant, a lipoprotein comprised of phospholipids (~80%), cholesterol (~10%), and proteins (~10%), functions to reduce surface tension and prevents alveolar collapse at end expiration [ 4 ] . The surfactant-associated proteins (SP) A, B, C and D, which are required for proper surfactant function, are developmentally and hormonally regulated [ 4 ] . We, and others, have shown that the SP-A levels in the amniotic fluid of diabetic mothers are significantly decreased [ 1 ] . Low SP-A levels in amniotic fluid have been correlated with an increased incidence of neonatal RDS [ 5 ] . Our previous studies have shown that insulin down-regulates SP-A mRNA and protein levels in human lung epithelial cells in a concentration and time-dependent manner via an inhibition of gene transcription [ 6 7 ] .
The mutagens permit direct selection of clones in which cellular genes have been disrupted and simplify the characterisation of genes associated with recessive mutations [ 1 ] . Mutagenesis of embryo-derived stem (ES) cells, coupled with in vitro genetic screens, has been widely used to analyse gene functions in mice [ 1 ] . These have included screens for mutations in developmentally regulated genes [ 2 3 4 5 ] , in genes regulated by extracellular agonists [ 6 7 ] , and in genes encoding secreted and transmembrane proteins [ 8 9 ] . Characterized mutations include genes involved in intracellular trafficking [ 10 ] , transcriptional regulation [ 11 12 ] , signal transduction [ 7 8 11 13 14 15 ] , neural development [ 16 ] and neural wiring [ 17 ] , and axial patterning [ 18 19 ] . The rapid expansion of the nucleic acid databases has had a tremendous impact on the identification of genes disrupted by gene entrapment.
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