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Example sentences for: dessaaae

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The human alpha-2C receptor, which has a DESSAAAE motif with only two hydroxyl residues, does not undergo down-regulation.
The human alpha-2C receptor, by contrast, has a DESSAAAE sequence in the same region [Figure 2; [ 22 ] ]. Thus, it is possible that the lack of desensitization and perhaps also down-regulation of the human alpha-2C receptor is due to the fact that there are only two hydroxyl residues in the DESSAAAE motif rather than the four hydroxyl residues in the alpha-2A EESSSSD motif.
The opossum alpha-2C adrenergic receptor has a very similar acidic serine motif (EESSTSE) in the third intracellular loop (Figure 1; [ 21 ] ), whereas the human alpha-2C receptor has a DESSAAAE sequence in the same region (Figure 2; [ 22 ] ). Thus, we postulated that the lack of down-regulation in the human alpha-2C was related to having only two rather than four serines in the motif, and furthermore that the ability of the opossum alpha-2C to undergo down-regulation was dependent on having all four serine/threonine residues in the EESSTSE motif.