Example sentences for: desimone

How can you use “desimone” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • DeSimone believes that he has identified the proton channel involved in sour taste as well as an ion channel that could be the second salt receptor, and he plans to do knockout experiments on both.

  • DeSimone's current idea is that strong acids enter taste cells through a proton channel (probably a known channel present on other cell types) while weak acids, like acetic acid (vinegar), enter as neutral molecules and then dissociate to lower intracellular pH.

  • In rats, says DeSimone, only 75% of the nerve response to salt can be blocked by amiloride, so there is probably a second receptor.

  • DeSimone suggests that by understanding salt receptors, it may be possible to design artificial ligands to help people lower their salt intake.

  • If these channels are essential elsewhere in the body, as DeSimone suspects, to avoid lethality he will need to construct conditional knockouts in which the channel is lost only in the taste receptor cells.


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