Words similar to desferrioxamine
Example sentences for: desferrioxamine
How can you use “desferrioxamine” in a sentence? Here are some example sentences to help you improve your vocabulary:
To many, deferiprone may not appear as a first-line chelator but rather as an alternative to desferrioxamine should the latter not be usable.
Indeed, the analyses indicate that desferrioxamine not only increases the likelihood of lowering hepatic iron load, but also tends to induce larger reductions in hepatic iron among responders, even after controlling for the imbalance in HIC at study initiation.
The studies identified were carefully evaluated for eligibility; they were included if they (i) enrolled subjects with thalassemia major - irrespective of age at diagnosis, treatment initiation or study start nor of treatment history in terms of transfusion regimen or iron chelation; (ii) followed patients treated with either desferrioxamine administered subcutaneously or intravenously or oral deferiprone; and (iii) measured hepatic iron concentrations to evaluate treatment efficacy.
The National Library of Medicine's computerized bibliographic database (Medline 1966 to December 1999) was searched using a combination of the following keywords: thalassemia, serum ferritin, urinary iron excretion, hepatic iron, liver, chelation therapy, iron chelation, iron chelating agents, desferal, desferrioxamine, deferoxamine, L1 oral chelate, deferiprone and 1,2-dimethyl-3-hydroxypyrid-4-one.
On the other hand, the results from the only randomized trial suggest that even at relatively low doses, desferrioxamine outperforms deferiprone [ 11 ] . Moreover, the toxic:therapeutic ratio of deferiprone is reportedly low; doses of 100 mg/kg/day have resulted in bone marrow toxicity in animals and humans.
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