Words similar to desferrioxamine
Example sentences for: desferrioxamine
How can you use “desferrioxamine” in a sentence? Here are some example sentences to help you improve your vocabulary:
A case-control study in 15 patients treated with deferiprone (cases) and 30 patients treated with desferrioxamine (controls) matched for age and serum ferritin levels, demonstrated that deferiprone appears to be more effective than desferrioxamine in removal of myocardial iron despite significantly higher HIC in the deferiprone group [ 5 ] . Although a larger prospective trial is needed to confirm the results, these findings would suggest that a combination of both drugs may be most beneficial in order to reduce both hepatic and myocardial concentrations of iron.
The studies identified were carefully evaluated for eligibility; they were included if they (i) enrolled subjects with thalassemia major - irrespective of age at diagnosis, treatment initiation or study start nor of treatment history in terms of transfusion regimen or iron chelation; (ii) followed patients treated with either desferrioxamine administered subcutaneously or intravenously or oral deferiprone; and (iii) measured hepatic iron concentrations to evaluate treatment efficacy.
As initial hepatic iron load was greater, on average, in patients receiving desferrioxamine, the comparison of the means needed to take this into account.
3 mg/g) deferiprone (overall p < 0.0001; p = 0.06 and p = 0.0002 for pairwise comparisons of desferrioxamine vs optimal and low dose deferiprone, respectively).
On the other hand, the results from the only randomized trial suggest that even at relatively low doses, desferrioxamine outperforms deferiprone [ 11 ] . Moreover, the toxic:therapeutic ratio of deferiprone is reportedly low; doses of 100 mg/kg/day have resulted in bone marrow toxicity in animals and humans.
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