Example sentences for: demethylating

How can you use “demethylating” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The effect of methylation on gene expression was similarly assessed on total RNA isolated from cell lines treated with the demethylating agent 5-Aza-2' deoxycytidine (Sigma) for five days at a concentration of 2-5 μM.

  • 2% of CC [ 13 ] . HIC1 is a zinc finger transcription factor that is transcriptionally silenced by promoter methylation in several types of human cancer [ 26 ] . Heterozygous Hic1 mouse with promoter methylation of wild type allele develop carcinomas, sarcomas and lymphomas, suggesting that this gene acts as a tumor suppressor gene [ 27 ] . HIC1 gene was down regulated in majority of the CC cell lines examined by us and this down-regulated expression was reactivated upon treatment with demethylating and HDAC-inhibiting agents.

  • Our data, therefore, suggest that the CC patients showing RARB promoter methylation may benefit from targeted chemopreventive treatment of combination of retinoic acid, demethylating, and chromatin modifying agents that reactivate the gene expression.

  • The remaining five cell lines neither showed evidence of decreased mRNA nor any effect of demethylating or HDAC-inhibiting agents on expression levels.

  • Treatment with demethylating and deacetylating inhibitor did not activate the expression in any cell line regardless of promoter methylation.


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