Example sentences for: dek

How can you use “dek” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Preparation of partially purified recombinant DEK protein

  • 4, lane 5), leaving a residual band (arrow) which can be attributed to distinct DEK binding activity.

  • DEK is a nuclear protein that is not structurally related to any known family of proteins [ 12 13 ] . Although it may also participate in DNA replication and RNA processing [ 14 15 ] , we have identified DEK as a DNA-binding protein that recognizes the TG-rich peri- ets (pets) regulatory element in the human immunodeficiency virus type 2 (HIV-2) enhancer [ 16 ] . The pets site is important in mediating HIV-2 enhancer stimulation in activated T cells and monocytes [ 17 18 19 ] , suggesting that DEK may play an immunomodulatory role as it participates in transcriptional activation through this and related sites.

  • The C-terminal region of DEK, which contains the putative DNA-binding domain, appears to be most antigenic [ 34 ] (and K Sitwala and DM Markovitz, unpublished observations), raising the possibility that altered DNA binding may expose other masked epitopes.

  • DEK has been shown to bind to the HIV-2 pets site [ 16 ] , but oligonucleotides containing this sequence also failed to compete significantly (lane 9), suggesting that factors other than DEK play a role in determining the specificity of this complex.


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