Words similar to dek
Example sentences for: dek
How can you use “dek” in a sentence? Here are some example sentences to help you improve your vocabulary:
As the Y-box promoter element is crucial to the regulation of MHC class II gene expression, sequence-specific binding to this motif indicates a potential role for DEK in modulating normal and abnormal immune response.
1) first led us to investigate whether DEK in nuclear extracts binds to MHC class II Y-box regulatory elements in vitro . With a double-stranded oligonucleotide probe containing the HLA-DQA1*0101 Y-box sequence, EMSAs revealed similar binding activity in nuclear extracts from B lymphoid (Namalwa), T lymphoid (Jurkat, CEM), monocytoid (U937), and HeLa cell lines (Fig.
DEK is a nuclear protein that is not structurally related to any known family of proteins [ 12 13 ] . Although it may also participate in DNA replication and RNA processing [ 14 15 ] , we have identified DEK as a DNA-binding protein that recognizes the TG-rich peri- ets (pets) regulatory element in the human immunodeficiency virus type 2 (HIV-2) enhancer [ 16 ] . The pets site is important in mediating HIV-2 enhancer stimulation in activated T cells and monocytes [ 17 18 19 ] , suggesting that DEK may play an immunomodulatory role as it participates in transcriptional activation through this and related sites.
HLA-DRA Y-box sequence to compete with the DQA1*0501 probe again indicates the relative importance of the adenine residue immediately 5' to the reverse CCAAT for DEK binding.
In this study, we examine the characteristics of DEK binding to the Y-box sequences of DQA1*0101, DQA1*0501, DRA, DQB , and DRB . We also confirm participation of DEK with NF-Y in the DQA1 Y-box binding complex and localize specific DEK binding within this sequence.
Loading...