Words similar to dek

Example sentences for: dek

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Among children with pauciarticular JRA, DEK autoantibodies were significantly more common in those with JRA-associated uveitis than in those without eye disease [ 8 9 ] . DEK reactivity was also found to be strongly associated with onset of any JRA subtype before age 6 years [ 8 ] .
We have previously shown that activation of promyeloid cells causes dephosphorylation of DEK and diminished DEK binding to the HIV-2 long terminal repeat [ 16 17 32 ] . In this study, we show that rDEK can bind to the DQA1 Y box, and that DEK in nuclear extracts participates in the DQA1 Y-box binding complex in vitro . Thus, we propose a model in which intracellular signaling modulates the ability of DEK to bind DNA, causing alteration of MHC class II transcription.
Participation of both DEK and NF-Y in the DQA1 Y-box binding complex was confirmed by using high-titer anti-DEK antiserum (gift of W Szer [ 9 ] ) and monoclonal antibody to the NF-YA subunit of the Y-box binding factor (gift of JP-Y Ting) to further retard the mobility of the DQA1 Y-box binding complex ('supershifting') (Fig.
4, lane 5), leaving a residual band (arrow) which can be attributed to distinct DEK binding activity.
As the Y-box promoter element is crucial to the regulation of MHC class II gene expression, sequence-specific binding to this motif indicates a potential role for DEK in modulating normal and abnormal immune response.