Example sentences for: dek

How can you use “dek” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Recombinant protein was purified from bacterial lysates in accordance with the published method for the QIA express system (Qiagen, Valencia, CA, USA) with variations in Buffers B and D as noted in Additional file: 1. Procedures were carried out at 4°C; dialyzed recombinant DEK protein (rDEK) was stored at -80°C.

  • Transient transfection experiments in cultured cell lines have not proved useful in examining this model, for DEK is highly expressed in most cells of hematopoietic lineage, and further overexpression has resulted in apparently nonspecific downregulation of transcriptional activity (as might be predicted from [ 14 ] ). For this reason, we are currently pursuing other experimental approaches.

  • As shown in Table 1, DEK binds more strongly to Y-box sequences in either DQA1 allele than it does to any of the other DR - or DQ -related Y-box sequences.

  • DEK is a nuclear protein that is not structurally related to any known family of proteins [ 12 13 ] . Although it may also participate in DNA replication and RNA processing [ 14 15 ] , we have identified DEK as a DNA-binding protein that recognizes the TG-rich peri- ets (pets) regulatory element in the human immunodeficiency virus type 2 (HIV-2) enhancer [ 16 ] . The pets site is important in mediating HIV-2 enhancer stimulation in activated T cells and monocytes [ 17 18 19 ] , suggesting that DEK may play an immunomodulatory role as it participates in transcriptional activation through this and related sites.

  • As the Y-box promoter element is crucial to the regulation of MHC class II gene expression, sequence-specific binding to this motif indicates a potential role for DEK in modulating normal and abnormal immune response.

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