Example sentences for: dek

How can you use “dek” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The K d[app] for DEK binding to DQB is approximately four times that for the DQA1 sequences, whereas the K d[app] for DEK binding to the DRB Y-box sequences, especially the

  • The C-terminal region of DEK, which contains the putative DNA-binding domain, appears to be most antigenic [ 34 ] (and K Sitwala and DM Markovitz, unpublished observations), raising the possibility that altered DNA binding may expose other masked epitopes.

  • We have previously shown that activation of promyeloid cells causes dephosphorylation of DEK and diminished DEK binding to the HIV-2 long terminal repeat [ 16 17 32 ] . In this study, we show that rDEK can bind to the DQA1 Y box, and that DEK in nuclear extracts participates in the DQA1 Y-box binding complex in vitro . Thus, we propose a model in which intracellular signaling modulates the ability of DEK to bind DNA, causing alteration of MHC class II transcription.

  • Further characterization of rDEK binding to the polymorphic DQA1*0501 Y-box sequence and to the consensus ( HLA-DRA ) Y-box sequence establishes a relative hierarchy of DEK binding activity (Fig.

  • bp = base pair(s); EMSA = electrophoretic mobility shift assay; FLAG = Five NH 2 -terminally deleted epilope; MHC = Major histocompatibility complex; HIV = human immunodeficiency virus; JRA = juvenile rheumatoid arthritis; K d[app] = apparent dissociation constant; PCR = polymerase chain reaction; pets = peri- ets ; rDEK = recombinant DEK protein.


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