Words similar to deformability
Example sentences for: deformability
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Studies reported by different investigators have shown that a dietary intake of 10 % canola oil (as part of semi-purified diets) significantly shortened the life-span of SHRSP rats, with accumulation of phytosterols in plasma, red blood cells and tissues [ 15 17 18 19 21 22 ] . Lower red blood cell (RBC) membrane deformability, lower density of platelets, as well as a higher blood pressure were also observed, when compared to a SHRSP group fed with vegetable oils lower in phytosterols (10 % soybean oil vs. 10% canola oil).
TGFβ1 also supports the differentiation of fibroblasts into myofibroblasts, which are a major constituent of the granulation tissue [ 23 24 ] . The process depends upon the deformability of the ECM [ 17 25 ] and is mediated by the ED-A splice variant of fibronectin [ 26 27 ] . ED-A fibronectin is expressed in the initial stages of wound healing and along with collagen I is positively regulated by TGFβ1 [ 26 ] .
In an in vitro study using red cells from both healthy subjects and patients with SCD, Kuypers and coworkers [ 25 ] showed that the deformability and stability of SCD red cells could be altered by changing the fatty acid composition of the phosphatidylcholine (PC) molecules of the membrane.
The fatty acid composition of serum phospholipids is known to reflect the phospholipid composition of cell membranes [ 10 ] . Because the fatty acid composition of membrane phospholipids is a major determinant of membrane fluidity and function [ 11 ] , any alteration in fatty acid composition of membrane phospholipids could contribute to the red cell abnormalities seen in SCD, such as cation imbalance, dehydration, reduced deformability and hypercoagulability [ 12 13 ] .
The double-bond index of the red cells increased, indicating an increase in red cell membrane fluidity and deformability.