Words similar to deferiprone
Example sentences for: deferiprone
How can you use “deferiprone” in a sentence? Here are some example sentences to help you improve your vocabulary:
The studies identified were carefully evaluated for eligibility; they were included if they (i) enrolled subjects with thalassemia major - irrespective of age at diagnosis, treatment initiation or study start nor of treatment history in terms of transfusion regimen or iron chelation; (ii) followed patients treated with either desferrioxamine administered subcutaneously or intravenously or oral deferiprone; and (iii) measured hepatic iron concentrations to evaluate treatment efficacy.
Based on analyses of individual patient data from eight studies reporting on changes in HIC over time, desferrioxamine seems to be more effective than deferiprone in lowering hepatic iron in patients with thalassemia major.
Indeed, to our knowledge, only one randomized controlled trial comparing desferrioxamine and deferiprone has been conducted and results for that study are incomplete as the trial was terminated prematurely and has not been reported in full [ 9 10 11 ] .
The literature on desferrioxamine and deferiprone lacks consensus on their comparative effectiveness and even on the methods for its quantification.
In the first study, 144 patients with thalassemia major and relatively low serum ferritin concentrations (1,500 - 3,000 ng/mL) were randomized to either deferiprone (n = 71) or desferrioxamine (n = 73) and followed for one year [ 28 ] . Although, the primary efficacy measure was the reduction of serum ferritin, HIC was assessed in a small subgroup of patients willing to undergo repeat liver biopsy: 21 in the deferiprone and 15 in the desferrioxamine group.
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