Example sentences for: de-localization

How can you use “de-localization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our data are consistent with results in sea urchin coelomocytes where BDM phenocopies the effect of cytochalasin D, blocking retrograde flow at the leading edge with continued contraction of the actin network causing a clearing of actin at the leading edge [ 11 ] . In the coelomyocte system, de-localization of leading edge components by BDM could account for the inhibition of actin polymerization and clearing.

  • Two possible mechanisms for Arp2/3 complex de-localization were considered: Arp2/3 could move back from the leading edge with retrograde flow of actin and then be lost from the filaments, or it could simply diffuse from the leading edge.

  • Data from studies of in vivo and in vitro filopodia formation suggest that they develop as a reorganization of the dendritic network in which they exist [ 29 30 ] . In the presence of proteins that bundle and reorganize actin filaments into filopodial precursors, the de-localization of Arp2/3 and other leading edge components may lead to the formation of filopodia, which are then elongated as described above.

  • In all cases, the loss of Arp3-GFP at the leading edge was seen concomitantly with loss of ruffling and retraction of the leading edge or as de-localization with slight retraction.

  • The sensitivity of the leading edge is demonstrated by the observation that DMSO treatment at a concentration of 1% causes temporary inhibition of ruffling and concomitant Arp3 de-localization (Yarrow unpublished results).

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