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Example sentences for: dcm
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Therefore the HW/BW ratio was lower for hearts fromcarvedilol treated DCM animals compared to hearts from non-treatedDCM animals.
In addition to DCM with conduction system disease and variable skeletal muscle involvement, mutations in the Lamin A/C gene [OMIM 150330] have been shown to cause autosomal dominant [ 11 ] and autosomal recessive [ 12 ] Emery-Dreifuss Muscular Dystrophy (EDMD), autosomal dominant limb-girdle muscular dystrophy type 1B (LGMD) [ 13 ] , autosomal recessive type 2 Charcot-Marie Tooth type 2 [ 14 ] , familial partial lipodystrophy [ 15 16 ] , Mandibuloacral dysplasia [ 17 ] and Hutchinson-Gilford progeria [ 18 ] . The phenotypic spectrum from DCM to EDMD and limb girdle muscular dystrophy appears continuous.
2 locus [ 9 ] . Mutations in the LMNA gene associated with DCM have a more severe prognosis and higher-event rates compared to individuals with DCM that do not have LMNA mutations [ 20 ] . A recent report describing another family with a LMNA mutation causing DCM and conduction system disease documents the need for permanent pacemaker implantation [ 21 ] . Previous reports on the proband's kindred support a high-event rate in family members often resulting in sudden cardiac death even in family members with permanent pacemakers [ 10 ] . For example, ten out of 38 family members with pacemakers for high-grade atrioventricular block died suddenly.
64 ± 0.49% vs. 1.72 ± 0.12% DCM andcontrol respectively, p < 0.001), indicating the occurrence ofapoptosis (Figure 2B).
DCM 11.
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