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Example sentences for: dapk

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Of the six cell lines with down regulated expression, 2 had promoter methylation and 4 had unmethylated promoter of the DAPK gene.
DAPK gene is methylated in 43.
The primers used for amplification of methylated and unmethylated promoters of genes RARB , TIMP3 , CDKN2A , p14 ARF , MGMT , DAPK , CDH1 , GSTP1 , APC promoter 1A, RB1 , MLH1 , TP73 , BRCA1 , FHIT , and HIC1 have been described previously http://pathology2.jhu.edu/pancreas/prim0425.htm#MSP; [ 32 47 48 49 ] . Methylated (MF and MR) and unmethylated (UF and UR) primers for RASSF1A promoter were designed according to Herman et al [ 46 ] and as described earlier [ 50 ] . PCR products were run on 2% agarose gels and visualized after ethidium bromide staining.
1%; DAPK , 43.
Dong and co-workers also previously showed promoter methylation in 51% of CC [ 13 ] . DAPK is a positive mediator of the programmed cell death induced by gamma-interferon [ 21 ] . Loss of DAPK expression has been shown to occur in a number of human malignancies, primarily by promoter hypermethylation [ 11 ] . It has also been shown that loss of DAPK gene expression was associated with aggressive and metastatic phenotype in many tumor types [ 22 ] . In the present study, in addition to showing high frequency of promoter methylation of DAPK gene, we found a complete lack of expression in two of the methylated cell lines and four of 6 unmethylated cell lines.