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Example sentences for: dapk

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Dong and co-workers also previously showed promoter methylation in 51% of CC [ 13 ] . DAPK is a positive mediator of the programmed cell death induced by gamma-interferon [ 21 ] . Loss of DAPK expression has been shown to occur in a number of human malignancies, primarily by promoter hypermethylation [ 11 ] . It has also been shown that loss of DAPK gene expression was associated with aggressive and metastatic phenotype in many tumor types [ 22 ] . In the present study, in addition to showing high frequency of promoter methylation of DAPK gene, we found a complete lack of expression in two of the methylated cell lines and four of 6 unmethylated cell lines.
9%; 45 of 82 tumors) and DAPK (45.
CDH1, DAPK, RARB and HIC1 gene promoters are frequently methylated in CC
Of the six cell lines with down regulated expression, 2 had promoter methylation and 4 had unmethylated promoter of the DAPK gene.
To examine the biological role of promoter methylation in CC, we assessed the levels of mRNA by semi-quantitative RT-PCR in eight cell lines and compared with the respective control values obtained from the averages calculated from 2 normal cervix after normalization against ACTB . This analysis was performed on 7 genes ( CDH1 , DAPK , RARB , HIC1 , MGMT , RASSF1A , and MLH1 ) that exhibited methylation in one or more cell lines and primary tumors (Fig.