Words similar to dadle
Example sentences for: dadle
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First, the anti-Id mAb raised against an anti DADLE ( 10, 11) totally inhibited the δ-agonist ligand/anti-ligand interaction, showing a good anti-idiotypic activity.
A rat monoclonal anti-idiotypic antibody (anti-Id mAb; 8 mg/ml;), generated against an anti- D-Ala 2-D-Leu 5-Enkephalin (DADLE) antibody and displaying affinity for δ-opioid receptors ( 10, 12), was used as the primary antibody.
At concentrations of 10 μM, neither DSLET, DADLE, nor DPDPE were found to increase the tyrosine phosphorylation of the IR or the PDGFR, whereas insulin (100 ng/ml) or PDGF (50 ng/ml) induced significant tyrosine phosphorylation of these sites (Figure 8).
In vitro studies carried out on NG108-15, a neurohybrid cell expressing δ-opioid receptors, showed internalization after the application of opioid agonists in bath medium, like DADLE or etorphin ( 9, 31).
Third, in rat spinal cord ( 12), we found that preincubation of fixed tissue with specific δ-opioid ligands (DADLE, Met-enkephalin, dermenkephalin and naltrindole at 10 -9M) totally prevented the antibody labeling, showing a good competition between ligands and the anti-Id mAb.