Words similar to cyab
Example sentences for: cyab
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CyaB homologs from Aeromonas , Clostridium, Borrelia , and Ralstonia lie firmly (RELL Bootstrap >= 70%) within the archaeal and eukaryotic clusters, rather than with their bacterial counterparts (Fig.
We show that Aeromonas adenylyl cyclase CyaB and thiamine triphosphatase define a novel superfamily of catalytic domains that act on nucleotides and organo-phosphate substrates.
Experimental analysis on the Methanococcus CyaB homolog revealed no adenylyl cyclase activity comparable to that seen in Aeromonas CyaB [ 16 ] . Likewise, there is no evidence for a widespread presence of the ThTPase activity in the organisms that contain CYTH domain proteins [ 17 ] . Hence, the principal biological function of the CYTH domains may be different from those of the experimentally characterized members of this family.
Given that the CYTH domain is the only globular domain in the enzymes, thiamine triphosphatase and CyaB, it is predicted to be an enzymatic domain.
Analogous active sites, that coordinate two metal ions, are observed in domains with similar activities, such as the classical adenylyl/guanylyl cyclases, family B DNA polymerases, pol-β fold nucleotidyl transferases, and triphosphatases or phosphoesterases of the HD and DHH superfamilies [ 11 15 19 20 ] . Consistent with these observations, both CyaB and ThTPase have been shown to require Mg 2+ions for their nucleotide cyclase and phosphatase activities [ 16 17 ] .