Example sentences for: cvid
How can you use “cvid” in a sentence? Here are some example sentences to help you improve your vocabulary:
The inheritance of certain polymorphisms of the mannose-binding lectin gene on Ch10 in persons with CVID are associated with earlier age of onset of manifestations of antibody deficiency and with increased risk of autoimmunity [ 25 ] . Altogether, these observations are consistent with the hypothesis that many common heritable antibody deficiency phenotypes collectively diagnosed as CVID or IgGSD are the result of the inheritance of multiple disease-predisposing alleles on Ch6p and possibly other chromosomes.
Eight of the present index patients (3 CVID, 5 IgGSD; 2 men, 6 women) also had hemochromatosis associated with homozygosity for
These observations could be explained by the occurrence of an HLA-linked allele that is necessary to cause either CVID or IgGSD, but is insufficient to induce a specific immunoglobulin deficiency phenotype.
Further, this implies that putative Ch6p alleles associated with CVID or IgGSD susceptibility occur on many HLA haplotypes that are common in Caucasians in central Alabama [ 10 ] and in Caucasians from a large national bone marrow donor program [ 14 ] . The present observations also confirm and extend the reports of association of HLA haplotype A*01-B*08 (or an extended haplotype containing A*01 and B*08) with heritable forms of immunoglobulin deficiency demonstrated in family-based analyses [ 3 6 19 20 21 22 ] . It is likely that a candidate gene(s) for CVID or IgGSD exists in the HLA class II region, [ 6 19 20 21 22 23 ] . Because the class II region is closer to the HLA-B locus than to the HLA-A locus, it is plausible that candidate gene(s) for CVID or IgGSD in the class II region are in greater linkage disequilibrium with HLA-B than HLA-A.
Some of the haplotypes significantly associated with CVID and IgGSD in the present study also occur with significantly increased frequencies in central Alabama Caucasian hemochromatosis probands with homozygosity for HFE C282Y on Ch6p [ 10 ] . These haplotypes are A*03-B*07 and A*03-B*14 [ [ 10 ] ; present study].
Loading...