Words similar to cur

Example sentences for: cur

How can you use “cur” in a sentence? Here are some example sentences to help you improve your vocabulary:

Specifically, the agonist appears somewhat resistant to the inhibitory effect of cyclopamine and Cur61414.
Volpes ( volpe fox) were cunning, Orsinos ( orso bear) lumbering, Manzos ( manzo bullock) taciturn, Botolinos ( botolo snapping cur) irascible, Cagnas ( cagna bitch) surly, and Buffas ( buffa Sicilian dialect for toad) detestable.
The two Hh-signaling antagonists, KAAD-cyclopamine and Cur61414, have shown decreased potency on Smo act-expressing cells, leading to the speculation that they may bind this mutant form of Smo less well than the wild-type form [ 11 17 ] . We sought to determine whether the Hh agonist binds Smo actwith a higher affinity, an observation seen with certain ligands and constitutively active mutants of GPCRs [ 29 ] . To perform this experiment, we isolated membranes from cells transfected with a cDNA construct encoding a tryptophan-to-leucine mutation at residue 539 (W539L) of murine Smo.
It has been shown that the Hh-pathway antagonists cyclopamine and Cur61414 block signaling in a Ptc-independent manner [ 11 17 ] and therefore may act directly on Smo.
These results argue that the agonist activates the pathway downstream of the Hh-Ptc interaction while cyclopamine, Cur61414 and the agonist may act at a similar level in the Hh-signaling cascade.