Words similar to csapp
Example sentences for: csapp
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The additivity of statin- and PO-stimulated shedding is consistent with the hypothesis that statins act at or near the plasma membrane, prior to internalization of csAPP.
Treatment with atorvastatin increased csAPP by approximately 1.6-fold, similar to the effect of the drug on holoAPP (Figure 1), while sAPP α shedding was increased by approximately 7-fold ( p < 0.05).
Since csAPP levels were only slightly raised in the same statin-treated cells in which sAPP α shedding was dramatically increased, we interpret this disparity to indicate that the effector of statin-stimulated shedding is probably intrinsic to the plasma membrane.
In order to refine our localization of the subcellular target of statin action, we evaluated the steady-state levels of cell-surface APP (csAPP) in the absence or presence of statins.
Cells and media were harvested, and levels of sAPP α , holoAPP, and csAPP were measured.